Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 8/20 | 0.54 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8076004 | 0.89 | BRS3 (0.46) | BRS3AGTR1AGTR2 | |
| SCHEMBL6534662 | 0.88 | BRS3 (0.48) | BRS3AGTR1AGTR2 | |
| SCHEMBL6534730 | 0.87 | BRS3 (0.52) | BRS3AGTR1AGTR2 | |
| SCHEMBL6534844 | 0.85 | BRS3 (0.46) | BRS3AGTR1AGTR2 | |
| SCHEMBL3460737 | 0.83 | PPARG (0.40) | BRS3AGTR1AGTR2 | |
| SCHEMBL7322921 | 0.83 | BRS3 (0.49) | BRS3 | |
| SCHEMBL7315650 | 0.82 | BRS3 (0.48) | BRS3AGTR1AGTR2 | |
| SCHEMBL7050688 | 0.80 | AGTR1 (0.34) | BRS3AGTR1AGTR2 | |
| SCHEMBL9205903 | 0.78 | BRS3 (0.43) | BRS3AGTR1AGTR2 | |
| SCHEMBL8070880 | 0.77 | XDH (0.36) | BRS3AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1059843-A1 | METHOD FOR DECREASING QT DISPERSION OR INHIBITING THE PROGRESSION OF QT DISPERSION WITH AN ANGIOTENSIN II RECEPTOR ANTAGONIST | Merck & Co., Inc. (US) | 2000-12-20 | — | — | EP | claimed |
| WO-1999043210-A1 | METHOD FOR DECREASING QT DISPERSION OR INHIBITING THE PROGRESSION OF QT DISPERSION WITH AN ANGIOTENSIN II RECEPTOR ANTAGONIST | MERCK & CO., INC. (US) | 1999-09-02 | — | — | WO | claimed |
| EP-0533840-A1 | TREATMENT OF CHRONIC RENAL FAILURE WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS. | DU PONT (US) | 1993-03-31 | — | — | EP | claimed |
| EP-0754042-A4 | TREATMENT OF ATHEROSCLEROSIS WITH ANGIOTENSIN II RECEPTOR BLOCKING IMIDAZOLES | MERCK & CO INC (US) | 2004-06-23 | — | — | EP | disclosed |
| EP-1059843-A1 | METHOD FOR DECREASING QT DISPERSION OR INHIBITING THE PROGRESSION OF QT DISPERSION WITH AN ANGIOTENSIN II RECEPTOR ANTAGONIST | Merck & Co., Inc. (US) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999043210-A1 | METHOD FOR DECREASING QT DISPERSION OR INHIBITING THE PROGRESSION OF QT DISPERSION WITH AN ANGIOTENSIN II RECEPTOR ANTAGONIST | MERCK & CO., INC. (US) | 1999-09-02 | — | — | WO | disclosed |
| EP-0754042-A1 | TREATMENT OF ATHEROSCLEROSIS WITH ANGIOTENSIN II RECEPTOR BLOCKING IMIDAZOLES | MERCK & CO. INC. (US) | 1997-01-22 | — | — | EP | disclosed |