Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 9/20 | 0.36 |
| ▸ | REN | P00797 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PEPD | P12955 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6560015 | 0.77 | LMNA (0.32) | LMNA | |
| SCHEMBL3924487 | 0.76 | ACE (0.41) | LMNAHSD17B10CYP2C19ACEREN | |
| SCHEMBL28261258 | 0.76 | ACE (0.41) | LMNAHSD17B10CYP2C19ACEREN | |
| SCHEMBL9230240 | 0.72 | ACE (0.40) | LMNAHSD17B10CYP2C19ACEREN | |
| SCHEMBL6558727 | 0.72 | — | — | |
| SCHEMBL10906984 | 0.71 | ACE (0.41) | LMNAHSD17B10CYP2C19ACEREN | |
| SCHEMBL28267035 | 0.69 | ACE (0.43) | LMNAHSD17B10CYP2C19ACEREN | |
| SCHEMBL3462968 | 0.68 | HSD17B10 (0.49) | LMNAHSD17B10CYP2C19ACEREN | |
| SCHEMBL10037292 | 0.68 | HSD17B10 (0.49) | LMNAHSD17B10CYP2C19ACEREN | |
| SCHEMBL1905956 | 0.68 | HSD17B10 (0.49) | LMNAHSD17B10CYP2C19ACEREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1146855-A4 | THERAPEUTIC DELIVERY USING COMPOUNDS SELF-ASSEMBLED INTO HIGH AXIAL RATIO MICROSTRUCTURES | UNIV WASHINGTON (US) | 2004-06-16 | — | — | EP | disclosed |
| EP-1146855-A1 | THERAPEUTIC DELIVERY USING COMPOUNDS SELF-ASSEMBLED INTO HIGH AXIAL RATIO MICROSTRUCTURES | University of Washington (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6180114-B1 | A DEVICE-FREE METHOD BY WHICH LIGANDS, SUCH AS DRUGS, CAN BE RELEASED INTO THE BODY, PARTICULARLY IN CONTINUOUS MANNER THROUGH ASSOCIATION WITH HIGH AXIAL RATIO MICROSTRUCTURES (HARMS) | UNIVERSITY OF WASHINGTON | 2001-01-30 | — | — | US | disclosed |
| WO-2000037046-A1 | THERAPEUTIC DELIVERY USING COMPOUNDS SELF-ASSEMBLED INTO HIGH AXIAL RATIO MICROSTRUCTURES | UNIVERSITY OF WASHINGTON (US) | 2000-06-29 | — | — | WO | disclosed |
| US-5851536-A | Therapeutic delivery using compounds self-assembled into high axial ratio microstructures | UNIVERSITY OF WASHINGTON (US) | 1998-12-22 | — | — | US | disclosed |