Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TACR3 | P29371 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 4/20 | 0.46 |
| ▸ | NAAA | Q02083 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7382237 | 0.78 | MAPT (0.52) | MEN1KMT2AKDM4E | |
| SCHEMBL16721552 | 0.75 | BRD4 (0.64) | ALDH1A1GLAHPGDSMN1; SMN2 | |
| SCHEMBL6439934 | 0.74 | ALDH1A1 (0.47) | ALDH1A1GLAHPGDTACR3POLB | |
| SCHEMBL6535800 | 0.72 | ALDH1A1 (0.64) | ALDH1A1TSHRSMN1; SMN2TACR3POLB | |
| SCHEMBL7050115 | 0.72 | TSHR (0.57) | ALDH1A1GLAHPGDTSHRSMN1; SMN2 | |
| SCHEMBL6535855 | 0.72 | ALDH1A1 (0.48) | ALDH1A1GLAHPGDTSHRL3MBTL1 | |
| SCHEMBL12385822 | 0.71 | ALDH1A1 (0.67) | ALDH1A1GLAHPGDTSHRSMN1; SMN2 | |
| SCHEMBL4113820 | 0.71 | ALDH1A1 (0.68) | ALDH1A1GLAHPGDTSHRSMN1; SMN2 | |
| SCHEMBL14197774 | 0.71 | ALDH1A1 (0.67) | ALDH1A1GLAHPGDTSHRSMN1; SMN2 | |
| SCHEMBL8060133 | 0.70 | L3MBTL1 (0.58) | ALDH1A1GLAHPGDTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318806-A4 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-01-21 | — | — | EP | disclosed |
| EP-1318806-A1 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024197-A1 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-03-28 | — | — | WO | disclosed |