Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 4/20 | 0.44 |
| ▸ | NAAA | Q02083 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | AMPD2 | Q01433 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4819758 | 0.74 | ALDH1A1 (0.50) | ALDH1A1HPGDGLAHSD11B1MEN1 | |
| SCHEMBL6535540 | 0.72 | ALDH1A1 (0.54) | ALDH1A1HPGDGLAHSD11B1FAAH | |
| SCHEMBL6535800 | 0.71 | ALDH1A1 (0.64) | ALDH1A1HSD11B1FAAHNAAAKMT2A | |
| SCHEMBL4819767 | 0.71 | CRBN (0.58) | ALDH1A1HPGDHSD11B1MEN1KMT2A | |
| SCHEMBL4819750 | 0.71 | CRBN (0.58) | ALDH1A1HPGDHSD11B1MEN1KMT2A | |
| SCHEMBL10870338 | 0.69 | ELANE (0.55) | ALDH1A1HPGDMEN1KMT2ATSHR | |
| SCHEMBL11377517 | 0.69 | HSD17B10 (0.67) | ALDH1A1HSD11B1FAAHNAAATSHR | |
| SCHEMBL6439273 | 0.69 | LMNA (0.58) | ALDH1A1HPGDGLAHSD11B1FAAH | |
| SCHEMBL16337701 | 0.69 | NAAA (0.83) | ALDH1A1HSD11B1FAAHNAAA | |
| SCHEMBL16336500 | 0.68 | ALDH1A1 (0.51) | ALDH1A1HSD11B1FAAHNAAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318806-A4 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-01-21 | — | — | EP | disclosed |
| EP-1318806-A1 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024197-A1 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-03-28 | — | — | WO | disclosed |