Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPN | P05981 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17059032 | 0.82 | COMT (0.49) | ALDH1A1MAPTPOLBKDM4ESMN1; SMN2 | |
| SCHEMBL16342649 | 0.77 | SMN1; SMN2 (0.53) | ALDH1A1MAPTMEN1KMT2APOLB | |
| SCHEMBL85578 | 0.77 | SCN2A (0.54) | ALDH1A1MAPTMEN1KMT2APOLB | |
| SCHEMBL16014801 | 0.74 | ALDH1A1 (0.46) | ALDH1A1MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL85896 | 0.73 | HPGD (0.52) | TSHRALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL5806805 | 0.72 | HSD17B10 (0.40) | TSHRALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL6535778 | 0.72 | HSP90AA1 (0.52) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL6535794 | 0.71 | TAS2R14 (0.41) | TSHRALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL27693543 | 0.70 | CYP3A4 (0.42) | TSHRALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL635130 | 0.70 | TSHR (0.90) | TSHRACHEALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670242-A1 | AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF | Genoa Pharmaceuticals, Inc. (US) | 2013-12-11 | — | — | EP | disclosed |
| WO-2012106382-A1 | AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF | GENOA PHARMACEUTICALS, INC. (US) | 2012-08-09 | — | — | WO | disclosed |
| EP-1261338-A4 | COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY | CYMAR INC (US) | 2004-05-06 | — | — | EP | disclosed |
| EP-1261338-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY | Cymar, Inc. (US) | 2002-12-04 | — | — | EP | disclosed |
| WO-2001062253-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY | CYMAR, INC. (US) | 2001-08-30 | — | — | WO | disclosed |