SCHEMBL6535853

SCHEMBL6535853

COc1ccc(-n2ccccc2=O)cc1C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
F10 P00742 6/20 0.46
CYP19A1 P11511 3/20 0.44
NQO2 P16083 3/20 0.44
CYP3A4 P08684 2/20 0.41
CYP2C9 P11712 2/20 0.41
GAA P10253 1/20 0.39
MAPT P10636 1/20 0.39
THRB P10828 1/20 0.39
MEN1 O00255 1/20 0.39
ALDH1A1 P00352 1/20 0.39
KMT2A Q03164 1/20 0.39
TUBB4A P04350 1/20 0.39
TUBB P07437 1/20 0.39
TUBA3C P0DPH7 1/20 0.39
TUBA1B P68363 1/20 0.39
TUBA4A P68366 1/20 0.39
TUBB4B P68371 1/20 0.39
TUBB3 Q13509 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9529067 0.87 CYP1A2 (0.60) CYP1A2L3MBTL1F10CYP2C9GAA
SCHEMBL13907449 0.81 KMT2A (0.53) CYP1A2F10CYP3A4GAAMAPT
SCHEMBL10059452 0.79 ALDH1A1 (0.51) CYP1A2CYP19A1NQO2GAAMAPT
SCHEMBL8160058 0.79 CYP1A2 (0.46) CYP1A2L3MBTL1F10CYP3A4GAA
SCHEMBL29132992 0.79 CYP1A2 (0.46) CYP1A2L3MBTL1F10CYP3A4CYP2C9
SCHEMBL28328775 0.79 ALDH1A1 (0.49) CYP1A2L3MBTL1F10ALDH1A1
SCHEMBL12545383 0.77 CYP1A2 (0.43) CYP1A2L3MBTL1F10CYP3A4CYP2C9
SCHEMBL1029269 0.77 THRB (0.44) CYP1A2F10CYP3A4CYP2C9GAA
SCHEMBL12955970 0.77 F10 (0.38) CYP1A2F10NQO2CYP3A4CYP2C9
SCHEMBL8149820 0.76 PDE5A (0.46) CYP1A2L3MBTL1F10CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1261338-A4 COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY CYMAR INC (US) 2004-05-06 EP disclosed
EP-1261338-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY Cymar, Inc. (US) 2002-12-04 EP disclosed
WO-2001062253-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF EPILEPSY CYMAR, INC. (US) 2001-08-30 WO disclosed