Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 2/20 | 0.35 |
| ▸ | ERN1 | O75460 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | CDC14B | O60729 | 1/20 | 0.33 |
| ▸ | CDC14A | Q9UNH5 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28469736 | 0.83 | MEN1 (0.35) | MEN1RAB9AKMT2AKIF11ERN1 | |
| SCHEMBL27880998 | 0.82 | BACE1 (0.38) | MEN1RAB9AKMT2AARERN1 | |
| SCHEMBL6536407 | 0.79 | HSD11B1 (0.41) | MEN1RAB9AKMT2AARALDH1A1 | |
| SCHEMBL29914889 | 0.79 | KIF11 (0.47) | KIF11ALDH1A1HPGDHSD11B1S1PR1 | |
| SCHEMBL28470496 | 0.78 | KMT2A (0.36) | MEN1RAB9AKMT2AARKIF11 | |
| SCHEMBL6900573 | 0.78 | KIF11 (0.39) | MEN1KMT2AKIF11ERN1ALDH1A1 | |
| SCHEMBL28338084 | 0.75 | MEN1 (0.46) | MEN1RAB9AKMT2AALDH1A1HPGD | |
| SCHEMBL2597833 | 0.74 | HSD11B1 (0.51) | ARKIF11ALDH1A1HPGDHSD11B1 | |
| SCHEMBL29702049 | 0.74 | KIF11 (0.36) | ARKIF11ALDH1A1HPGDCDC14B | |
| SCHEMBL29723384 | 0.74 | BACE1 (0.39) | KIF11ERN1ALDH1A1HPGDCDC14B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425015-A4 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-1425015-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003015715-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-02-27 | — | — | WO | disclosed |