Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 3/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28336820 | 0.81 | NFKB1 (0.45) | MEN1KMT2ANFKB1CES1MAOB | |
| SCHEMBL989191 | 0.80 | NFKB1 (0.44) | MEN1KMT2ANFKB1ALDH1A1HPGD | |
| SCHEMBL954787 | 0.80 | MEN1 (0.53) | MEN1RAB9AKMT2AALDH1A1HPGD | |
| SCHEMBL28204257 | 0.79 | MEN1 (0.38) | MEN1RAB9AKMT2AALDH1A1HPGD | |
| SCHEMBL6535912 | 0.79 | MEN1 (0.38) | HSD11B1MEN1RAB9AKMT2AAR | |
| SCHEMBL28321711 | 0.79 | MEN1 (0.47) | HSD11B1MEN1KMT2AARNFKB1 | |
| SCHEMBL2597833 | 0.77 | HSD11B1 (0.51) | HSD11B1ARFFAR4ALDH1A1HPGD | |
| SCHEMBL163729 | 0.76 | HSD11B1 (0.55) | HSD11B1ARFFAR4ALDH1A1HPGD | |
| SCHEMBL9754447 | 0.76 | KMT2A (0.42) | MEN1RAB9AKMT2AALDH1A1HPGD | |
| SCHEMBL6535972 | 0.75 | FFAR4 (0.43) | MEN1RAB9AKMT2AFFAR4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425015-A4 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-1425015-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003015715-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-02-27 | — | — | WO | disclosed |