Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CKS1B | P61024 | 1/20 | 0.45 |
| ▸ | SKP1 | P63208 | 1/20 | 0.45 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.45 |
| ▸ | ACACB | O00763 | 3/20 | 0.44 |
| ▸ | ACACA | Q13085 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.43 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10682348 | 0.90 | KMT2A (0.51) | KMT2AL3MBTL1CKS1BSKP1SKP2 | |
| SCHEMBL14290582 | 0.85 | OPRM1 (0.55) | KMT2AL3MBTL1DRD2OPRM1OPRD1 | |
| SCHEMBL9091685 | 0.85 | OPRM1 (0.55) | KMT2AL3MBTL1DRD2OPRM1OPRD1 | |
| SCHEMBL30500906 | 0.83 | NPFFR1 (0.50) | KMT2AL3MBTL1DRD2NPFFR1NPFFR2 | |
| SCHEMBL14357537 | 0.81 | SIGMAR1 (0.52) | KMT2AL3MBTL1DRD2NPFFR1NPFFR2 | |
| SCHEMBL17155200 | 0.81 | KMT2A (0.49) | KMT2AL3MBTL1DRD2NPFFR1NPFFR2 | |
| SCHEMBL6176499 | 0.80 | KMT2A (0.47) | KMT2AL3MBTL1CKS1BSKP1SKP2 | |
| SCHEMBL15722751 | 0.80 | SIGMAR1 (0.51) | KMT2AL3MBTL1NPFFR1NPFFR2SIGMAR1 | |
| SCHEMBL6176496 | 0.80 | KMT2A (0.47) | KMT2AL3MBTL1CKS1BSKP1SKP2 | |
| SCHEMBL31048352 | 0.79 | KMT2A (0.47) | KMT2AL3MBTL1NPFFR1NPFFR2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399160-A4 | NR2B RECEPTOR ANTAGONISTS FOR THE TREATMENT OR PREVENTION OF MIGRAINES | MERCK & CO INC (US) | 2004-08-25 | — | — | EP | disclosed |
| EP-1399160-A2 | NR2B RECEPTOR ANTAGONISTS FOR THE TREATMENT OR PREVENTION OF MIGRAINES | Merck & Co., Inc. (US) | 2004-03-24 | — | — | EP | disclosed |
| WO-2002100352-A2 | NR2B RECEPTOR ANTAGONISTS FOR THE TREATMENT OR PREVENTION OF MIGRAINES | MERCK & CO., INC. (US) | 2002-12-19 | — | — | WO | disclosed |