Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.43 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | ACACA | Q13085 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6176499 | 1.00 | KMT2A (0.47) | KMT2AL3MBTL1SCN9ANPFFR1NPFFR2 | |
| SCHEMBL31048352 | 0.94 | KMT2A (0.47) | KMT2AL3MBTL1SCN9ANPFFR1NPFFR2 | |
| SCHEMBL10682348 | 0.85 | KMT2A (0.51) | KMT2AL3MBTL1NPFFR1NPFFR2SIGMAR1 | |
| SCHEMBL5650658 | 0.84 | SCN9A (0.47) | SCN9AALDH1A1 | |
| SCHEMBL14290582 | 0.83 | OPRM1 (0.55) | KMT2AL3MBTL1SIGMAR1DRD2OPRM1 | |
| SCHEMBL9091685 | 0.83 | OPRM1 (0.55) | KMT2AL3MBTL1SIGMAR1DRD2OPRM1 | |
| SCHEMBL14357537 | 0.81 | SIGMAR1 (0.52) | KMT2AL3MBTL1NPFFR1NPFFR2SIGMAR1 | |
| SCHEMBL30452743 | 0.81 | MEN1 (0.46) | KMT2ASIGMAR1DRD2 | |
| SCHEMBL1597242 | 0.81 | SCN9A (0.49) | L3MBTL1SCN9AALDH1A1CKS1BSKP1 | |
| SCHEMBL15722751 | 0.80 | SIGMAR1 (0.51) | KMT2AL3MBTL1NPFFR1NPFFR2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6943160-B2 | Morpholine derivatives as antagonists of orexin receptors | SMITHKLINE BEECHAM PLC (GB) | 2005-09-13 | — | — | US | disclosed |
| EP-1353918-B1 | MORPHOLINE DERIVATIVES AS ANTAGONISTS OF OREXIN RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2005-01-12 | — | — | EP | disclosed |
| US-20040058921-A1 | Morpholine derivatives as antagonists of orexin receptors | SMITHKLINE BEECHAM PLC (GB) | 2004-03-25 | — | — | US | disclosed |
| EP-1353918-A1 | MORPHOLINE DERIVATIVES AS ANTAGONISTS OF OREXIN RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2003-10-22 | — | — | EP | disclosed |
| WO-2002044172-A1 | MORPHOLINE DERIVATIVES AS ANTAGONISTS OF OREXIN RECEPTORS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-06-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058921-A1 | Morpholine derivatives as antagonists of orexin receptors | HCRTR2, HCRTR1, OXTR | KMT2A 1246/4885L3MBTL1 4642/4885SCN9A 1431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.