Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.50 |
| ▸ | PTPRC | P08575 | 1/20 | 0.50 |
| ▸ | PTPRF | P10586 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | CDC25B | P30305 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.47 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2042640 | 0.86 | STIM1 (0.57) | ADORA3ADORA2AADORA2BKDM4EHSD17B10 | |
| SCHEMBL6773146 | 0.86 | KDM4E (0.56) | EGFRKDM4EHSD17B10CA1CA2 | |
| SCHEMBL29868499 | 0.86 | KDM4E (0.56) | EGFRKDM4EHSD17B10CA1CA2 | |
| SCHEMBL2050621 | 0.85 | EGFR (0.56) | PTPRCPTPRFPTPN1CDC25BPTGS1 | |
| SCHEMBL29788043 | 0.85 | EGFR (0.56) | PTPRCPTPRFPTPN1CDC25BPTGS1 | |
| SCHEMBL12844713 | 0.85 | ERN1 (0.52) | ADORA3ADORA2AADORA2BSTIM1ORAI1 | |
| SCHEMBL7359469 | 0.84 | STIM1 (0.47) | ADORA3ADORA2AADORA2BKDM4EHSD17B10 | |
| SCHEMBL27499555 | 0.83 | LMNA (0.58) | ADORA3ADORA2AADORA2BPTGS1KDM4E | |
| SCHEMBL28092583 | 0.78 | MGAM (0.54) | ADORA3ADORA2AADORA2BKDM4EHSD17B10 | |
| SCHEMBL4778742 | 0.78 | ALDH1A1 (0.56) | ADORA3ADORA2AADORA2BKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425015-A4 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-1425015-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003015715-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-02-27 | — | — | WO | disclosed |