SCHEMBL6536099

SCHEMBL6536099

NC(=O)c1ccc(Cl)c(NC(=O)Nc2ccc(C(F)(F)F)cc2)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.57
KMT2A Q03164 3/20 0.57
LMNA P02545 1/20 0.57
EPHX2 P34913 2/20 0.56
GRIK1 P39086 1/20 0.54
CA12 O43570 2/20 0.54
CA1 P00915 2/20 0.54
CA2 P00918 2/20 0.54
CA9 Q16790 2/20 0.54
MAPT P10636 4/20 0.53
TP53 P04637 1/20 0.53
GAA P10253 1/20 0.53
CHRNA7 P36544 1/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2D6 P10635 1/20 0.52
CYP2C19 P33261 1/20 0.52
RIPK1 Q13546 2/20 0.51
FLT1 P17948 1/20 0.51
TEK Q02763 1/20 0.51
KDR P35968 3/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3460836 0.82 MEN1 (0.56) MEN1KMT2ALMNAEPHX2GRIK1
SCHEMBL6815018 0.79 CA12 (0.65) MEN1KMT2AEPHX2CA12CA1
SCHEMBL15435517 0.79 CYP1A2 (0.62) MEN1KMT2ALMNAEPHX2GRIK1
SCHEMBL20472469 0.79 CHRNA7 (0.76) MEN1KMT2ALMNAMAPTTP53
SCHEMBL29776952 0.79 CHRNA7 (0.76) MEN1KMT2ALMNAMAPTTP53
SCHEMBL13613542 0.79 KDR (0.69) MEN1KMT2ALMNAGRIK1CA12
SCHEMBL7162138 0.77 KDR (0.78) CA1CA2CA9KDR
SCHEMBL11007737 0.77 MEN1 (0.61) MEN1KMT2ALMNAMAPTTP53
SCHEMBL4964795 0.77 RIPK1 (0.58) MEN1KMT2ALMNACA12CA1
SCHEMBL4348880 0.76 EPHX2 (0.69) MEN1KMT2AEPHX2GRIK1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1303559-A4 ACTIVATED MODULAR GRAFTED POLYMERIC SURFACES MIMOTOPES PTY LTD (AU) 2004-06-30 EP disclosed
US-20040076623-A1 Activated modular grafted polymeric surfaces MIMOTOPES PTY LTD (AU) 2004-04-22 US disclosed
EP-1303559-A1 ACTIVATED MODULAR GRAFTED POLYMERIC SURFACES Mimotopes Pty Ltd (AU) 2003-04-23 EP disclosed
US-20020076835-A1 Modular grafted polymeric surfaces MIMOTOPES PTY. LTD. (AU) 2002-06-20 US disclosed
WO-2002006384-A1 ACTIVATED MODULAR GRAFTED POLYMERIC SURFACES MIMOTOPES PTY LTD (AU) 2002-01-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040076623-A1 Activated modular grafted polymeric surfaces SIGLEC7, PHAX, STUB1 MEN1 4762/4885KMT2A 3594/4885LMNA 3848/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.