Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.58 |
| ▸ | FLT1 | P17948 | 4/20 | 0.56 |
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 6/20 | 0.52 |
| ▸ | FLT3 | P36888 | 6/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.52 |
| ▸ | ABL1 | P00519 | 3/20 | 0.52 |
| ▸ | LCK | P06239 | 3/20 | 0.52 |
| ▸ | FYN | P06241 | 3/20 | 0.52 |
| ▸ | CSF1R | P07333 | 3/20 | 0.52 |
| ▸ | LYN | P07948 | 3/20 | 0.52 |
| ▸ | BLK | P51451 | 3/20 | 0.52 |
| ▸ | PLK4 | O00444 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 2/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.52 |
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.52 |
| ▸ | INSR | P06213 | 2/20 | 0.52 |
| ▸ | MET | P08581 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4964462 | 0.90 | KIT (0.64) | RIPK1FLT1TEKKITFLT3 | |
| SCHEMBL4966551 | 0.85 | RIPK1 (0.56) | RIPK1FLT1TEKKITFLT3 | |
| SCHEMBL4480358 | 0.79 | RIPK1 (0.53) | RIPK1FLT1TEKKITFLT3 | |
| SCHEMBL4962802 | 0.79 | ANO1 (0.49) | FLT1TEKKITFLT3NTRK1 | |
| SCHEMBL6536099 | 0.77 | MEN1 (0.57) | RIPK1FLT1TEKTP53GAA | |
| SCHEMBL4257211 | 0.77 | RIPK1 (0.53) | RIPK1FLT1TEKKITFLT3 | |
| SCHEMBL4964671 | 0.77 | KDR (0.55) | FLT1KITFLT3NTRK1ABL1 | |
| SCHEMBL4962777 | 0.76 | KIT (0.61) | RIPK1FLT1TEKKITFLT3 | |
| SCHEMBL19048693 | 0.76 | KDR (0.62) | FLT1TEKKITFLT3NTRK1 | |
| SCHEMBL4262663 | 0.76 | RIPK2 (0.58) | RIPK1FLT1TEKNTRK1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436279-B8 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-10-29 | — | — | EP | claimed |
| EP-1436279-B1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-08-13 | — | — | EP | claimed |
| US-7179836-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-20 | — | — | US | claimed |
| EP-1436279-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2005-10-26 | — | — | EP | claimed |
| US-20040192941-A1 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2004-09-30 | — | — | US | claimed |
| EP-1436279-A1 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2004-07-14 | — | — | EP | claimed |
| WO-2003027093-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-03 | — | — | WO | claimed |
| EP-1436279-B8 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-10-29 | — | — | EP | disclosed |
| EP-1436279-B1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-08-13 | — | — | EP | disclosed |
| EP-1436279-B1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-08-13 | — | — | EP | disclosed |
| US-7179836-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-20 | — | — | US | disclosed |
| US-7179836-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-20 | — | — | US | disclosed |
| US-7179836-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-20 | — | — | US | disclosed |
| EP-1436279-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2005-10-26 | — | — | EP | disclosed |
| US-20040192941-A1 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2004-09-30 | — | — | US | disclosed |
| EP-1436279-A1 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003027093-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192941-A1 | Chemical compounds | TPMT, TST, CYP11B2 | RIPK1 4198/4885FLT1 3362/4885TEK 3511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.