SCHEMBL6536361

SCHEMBL6536361

COc1ccc(C2(C3CCCN3C)C=Cc3ccccc3C2)c(C)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIN2D O15399 3/20 0.37
GRIN3B O60391 3/20 0.37
GRIN1 Q05586 3/20 0.37
GRIN2A Q12879 3/20 0.37
GRIN2B Q13224 3/20 0.37
GRIN2C Q14957 3/20 0.37
GRIN3A Q8TCU5 3/20 0.37
SLC6A4 P31645 2/20 0.37
SIGMAR1 Q99720 2/20 0.37
CYP2D6 P10635 2/20 0.37
SLC22A1 O15245 1/20 0.37
ADRA2A P08913 1/20 0.37
TSHR P16473 1/20 0.37
ADRA2C P18825 1/20 0.37
SLC6A2 P23975 1/20 0.37
TACR1 P25103 1/20 0.37
HTR2A P28223 1/20 0.37
ADRA1A P35348 1/20 0.37
OPRM1 P35372 1/20 0.37
OPRK1 P41145 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6861332 0.72 DRD1 (0.34) TSHRLMNADRD1DRD5DRD2
SCHEMBL2398391 0.69 FAAH (0.35) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL6536525 0.68 SMN1; SMN2 (0.34) HTR2ALMNADRD1DRD5DRD2
SCHEMBL9113335 0.64 MAPT (0.36) OPRM1LMNADRD1DRD5DRD2
SCHEMBL6536705 0.60 DRD1 (0.33) HTR2ALMNADRD1DRD5DRD2
SCHEMBL28333486 0.60 MAPT (0.39) HTR2ADRD2DRD3DRD4
SCHEMBL11086789 0.60 SLC6A4 (0.62) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL9327427 0.60 SLC6A4 (0.48) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL11642550 0.58 OPRM1 (0.44) SIGMAR1OPRM1DRD1DRD2DRD4
SCHEMBL11643363 0.58 CHRNB4 (0.43) SIGMAR1OPRM1DRD1DRD2DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1162482-B1 Synthetic resin laminate having both polarization characteristic and photochromism characteristic MITSUBISHI GAS CHEMICAL CO (JP) 2012-06-20 EP disclosed
US-6797383-B2 RESIN LAYER HAVING PHOTOCHROMISM CHARACTERISTIC AND RESIN LAYER HAVING POLARIZATION CHARACTERISTIC INTERPOSED BETWEEN TWO TRANSPARENT SYNTHETIC RESIN LAYERS, ADHESIVE LAYER; SUNGLASSES, SPORTS GOGGLES MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2004-09-28 US disclosed
EP-1273935-B1 TRANSPARENT SYNTHETIC RESIN LAMINATE HAVING PHOTOCHROMISM MITSUBISHI GAS CHEMICAL CO (JP) 2004-06-30 EP disclosed
EP-1273935-A1 TRANSPARENT SYNTHETIC RESIN LAMINATE HAVING PHOTOCHROMISM MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2003-01-08 EP disclosed
US-20020006505-A1 Synthetic resin laminate having both polariztion characteristic and photochromism characteristic MITSUBISHI GAS CHEMICAL COMPANY, INC. 2002-01-17 US disclosed