SCHEMBL6536705

SCHEMBL6536705

COc1ccc(C2(c3cccs3)C=Cc3ccccc3C2)c(F)c1

nearest known ligand 0.33

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
DRD1 P21728 7/20 0.33
DRD2 P14416 6/20 0.33
DRD5 P21918 6/20 0.33
DRD3 P35462 6/20 0.33
DRD4 P21917 5/20 0.33
PKM P14618 1/20 0.32
KMT2A Q03164 2/20 0.32
POLB P06746 1/20 0.32
HTR2A P28223 1/20 0.31
ICMT O60725 1/20 0.31
ALDH1A1 P00352 1/20 0.31
MAPT P10636 2/20 0.31
LMNA P02545 1/20 0.31
CRHR1 P34998 1/20 0.30
PPIB P23284 1/20 0.30
PDK2 Q15119 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6536500 0.75 ATM (0.34) POLBALDH1A1LMNA
SCHEMBL9113335 0.71 MAPT (0.36) DRD1DRD2DRD5DRD3DRD4
SCHEMBL9546931 0.68 MAOA (0.36) KMT2ALMNA
SCHEMBL20474534 0.67 OPRM1 (0.36) KMT2A
SCHEMBL6861332 0.67 DRD1 (0.34) DRD1DRD2DRD5DRD3DRD4
SCHEMBL6536525 0.67 SMN1; SMN2 (0.34) DRD1DRD2DRD5DRD3DRD4
SCHEMBL2401825 0.65 KDM4E (0.34) KMT2APOLBALDH1A1MAPTLMNA
SCHEMBL6689781 0.64 OPRM1 (0.32)
SCHEMBL6689248 0.64 HDAC9 (0.33) KMT2AALDH1A1
SCHEMBL23232232 0.61 KMT2A (0.46) KMT2AALDH1A1PDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1394595-B1 PLASTIC MOLDED PRODUCT HAVING PHOTOCHROMIC CHARACTERISTICS AND/OR POLARIZING CHARACTERISTICS MITSUBISHI GAS CHEMICAL CO (JP) 2013-05-01 EP disclosed
EP-1162482-B1 Synthetic resin laminate having both polarization characteristic and photochromism characteristic MITSUBISHI GAS CHEMICAL CO (JP) 2012-06-20 EP disclosed
US-6797383-B2 RESIN LAYER HAVING PHOTOCHROMISM CHARACTERISTIC AND RESIN LAYER HAVING POLARIZATION CHARACTERISTIC INTERPOSED BETWEEN TWO TRANSPARENT SYNTHETIC RESIN LAYERS, ADHESIVE LAYER; SUNGLASSES, SPORTS GOGGLES MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2004-09-28 US disclosed
EP-1273935-B1 TRANSPARENT SYNTHETIC RESIN LAMINATE HAVING PHOTOCHROMISM MITSUBISHI GAS CHEMICAL CO (JP) 2004-06-30 EP disclosed
EP-1394595-A1 PLASTIC MOLDED PRODUCT HAVING PHOTOCHROMIC CHARACTERISTICS AND/OR POLARIZING CHARACTERISTICS MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2004-03-03 EP disclosed
EP-1273935-A1 TRANSPARENT SYNTHETIC RESIN LAMINATE HAVING PHOTOCHROMISM MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2003-01-08 EP disclosed
US-20020006505-A1 Synthetic resin laminate having both polariztion characteristic and photochromism characteristic MITSUBISHI GAS CHEMICAL COMPANY, INC. 2002-01-17 US disclosed
EP-1162482-A2 Synthetic resin laminate having both polarization characteristic and photochromism characteristic MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2001-12-12 EP disclosed