Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | DNA2 | P51530 | 1/20 | 0.52 |
| ▸ | CASP6 | P55212 | 1/20 | 0.52 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.52 |
| ▸ | CCR8 | P51685 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8604489 | 0.81 | ALDH1A1 (0.53) | ALDH1A1PARP1DNA2CASP6CTDSP1 | |
| SCHEMBL6537755 | 0.77 | CHUK (0.48) | ALDH1A1CCR8KMT2AMAPTNPC1 | |
| SCHEMBL259909 | 0.77 | TDP1 (0.54) | ALDH1A1PARP1DNA2CASP6CTDSP1 | |
| SCHEMBL30275708 | 0.76 | DNA2 (0.56) | ALDH1A1PARP1DNA2CASP6CTDSP1 | |
| SCHEMBL1017079 | 0.76 | DNA2 (0.56) | ALDH1A1PARP1DNA2CASP6CTDSP1 | |
| SCHEMBL6538378 | 0.76 | DNA2 (0.63) | ALDH1A1PARP1DNA2CASP6CTDSP1 | |
| SCHEMBL6537634 | 0.76 | GRIN2D (0.49) | ALDH1A1TDP1CCR8KMT2AKDM4E | |
| SCHEMBL6538005 | 0.76 | CCR8 (0.43) | ALDH1A1DNA2CASP6CTDSP1TDP1 | |
| SCHEMBL11003986 | 0.74 | TDP1 (0.48) | ALDH1A1DNA2CASP6CTDSP1TDP1 | |
| SCHEMBL30799237 | 0.74 | TDP1 (0.48) | ALDH1A1DNA2CASP6CTDSP1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876345-B1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-08-18 | — | — | EP | disclosed |
| US-6008230-A | TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-12-28 | — | — | US | disclosed |
| EP-0876345-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997014681-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-24 | — | — | WO | disclosed |