Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | SUMO3 | P55854 | 1/20 | 0.39 |
| ▸ | SUMO2 | P61956 | 1/20 | 0.39 |
| ▸ | SUMO1 | P63165 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | PDE1A | P54750 | 3/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6539007 | 0.87 | PDE9A (0.39) | KDM4EHSD17B10HTTTP53HPGD | |
| SCHEMBL6135245 | 0.86 | CCNA2 (0.40) | KDM4ENPC1RAB9AHSD17B10HIF1A | |
| SCHEMBL6538385 | 0.85 | RET (0.41) | HSD17B10ADORA2AADORA1ALDH1A1FYN | |
| SCHEMBL6538465 | 0.83 | GPR84 (0.43) | KDM4ERAB9AHSD17B10HTTHIF1A | |
| SCHEMBL6538914 | 0.80 | TP53 (0.38) | KDM4EHSD17B10TP53ADORA2APDE1A | |
| SCHEMBL6133468 | 0.80 | ADORA2A (0.41) | KDM4ENPC1RAB9AHSD17B10SMN1; SMN2 | |
| SCHEMBL5147963 | 0.79 | HIF1A (0.43) | KDM4EHSD17B10HTTHIF1ASUMO3 | |
| SCHEMBL6133960 | 0.79 | ADORA2A (0.47) | KDM4EHTTHIF1ASUMO3SUMO2 | |
| SCHEMBL6539021 | 0.78 | TP53 (0.45) | KDM4ETP53SMN1; SMN2ADORA2AADORA1 | |
| SCHEMBL6539054 | 0.77 | LMNA (0.49) | KDM4ENPC1RAB9AHSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040067955-A1 | Pyridazinone compound and pharmaceutical use thereof | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2004-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040067955-A1 | Pyridazinone compound and pharmaceutical use thereof | ADORA1, ADORA2A, P2RX5 | KDM4E 3052/4885NPC1 1572/4885RAB9A 3144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.