Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.44 |
| ▸ | RAB9A | P51151 | 7/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6539853 | 1.00 | NPC1 (0.44) | NPC1RAB9ATP53POLBKMT2A | |
| SCHEMBL7691950 | 0.91 | MAPT (0.42) | NPC1RAB9ATP53POLBKMT2A | |
| SCHEMBL6538746 | 0.89 | PPARA (0.46) | NPC1RAB9APOLBKMT2ASMN1; SMN2 | |
| SCHEMBL6541438 | 0.81 | CAPN1 (0.38) | KMT2ASMN1; SMN2HPGDMAPTCA2 | |
| SCHEMBL6541442 | 0.81 | CAPN1 (0.38) | KMT2ASMN1; SMN2HPGDMAPTCA2 | |
| SCHEMBL6541124 | 0.81 | NAMPT (0.42) | CA1CA2 | |
| SCHEMBL6541230 | 0.81 | ALDH1A1 (0.39) | SMN1; SMN2HPGDMAPK1MAPTTSHR | |
| SCHEMBL6541226 | 0.81 | ALDH1A1 (0.39) | SMN1; SMN2HPGDMAPK1MAPTTSHR | |
| SCHEMBL6541119 | 0.81 | NAMPT (0.42) | CA1CA2 | |
| SCHEMBL6539634 | 0.80 | MAPT (0.38) | KMT2ASMN1; SMN2MEN1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6826033-B2 | BETA 3 ADRENERGIC RECEPTOR AGONISTS; TREATMENT OF POLLAKIURIA, URINARY INCONTINENCE, OBESITY OR DIABETES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| US-20040037022-A1 | Aminoalcohol derivatives | ASTELLAS PHARMA INC. (JP) | 2004-02-26 | — | — | US | disclosed |