Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 20/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17027040 | 0.82 | PDE7A (0.46) | PGR | |
| SCHEMBL21382173 | 0.75 | PDE7A (0.41) | — | |
| SCHEMBL6013866 | 0.74 | PGR (1.00) | PGR | |
| SCHEMBL4101423 | 0.74 | PGR (1.00) | PGR | |
| SCHEMBL7557572 | 0.73 | PGR (0.55) | PGR | |
| SCHEMBL15812245 | 0.72 | TNKS (0.50) | PGR | |
| SCHEMBL29851080 | 0.72 | PGR (0.58) | PGR | |
| SCHEMBL7658270 | 0.72 | PGR (0.58) | PGR | |
| SCHEMBL4167945 | 0.71 | PGR (0.65) | PGR | |
| SCHEMBL21537943 | 0.70 | TNKS (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1175397-B1 | 3,3-SUBSTITUTED INDOLINE DERIVATIVES | WYETH CORP (US) | 2004-08-18 | — | — | EP | claimed |
| US-20030008909-A1 | 3,3-substituted indoline derivatives | WYETH (US) | 2003-01-09 | — | — | US | claimed |
| US-6503939-B2 | That are antagonists of the progesterone receptor, in a female contraceptive kit | WYETH | 2003-01-07 | — | — | US | claimed |
| JP-2002543157-A | — | — | 2002-12-17 | — | — | JP | claimed |
| JP-2002543181-A | — | — | 2002-12-17 | — | — | JP | claimed |
| EP-1175397-A1 | 3,3-SUBSTITUTED INDOLINE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-01-30 | — | — | EP | claimed |
| EP-1173211-A1 | CONTRACEPTIVE COMPOSITIONS CONTAINING 3,3-SUBSTITUTED INDOLINE DERIVATIVES AND USES THEREOF | American Home Products Corporation (US) | 2002-01-23 | — | — | EP | claimed |
| WO-2000066554-A1 | 3,3-SUBSTITUTED INDOLINE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-09 | — | — | WO | claimed |
| WO-2000066166-A1 | CONTRACEPTIVE COMPOSITIONS CONTAINING 3,3-SUBSTITUTED INDOLINE DERIVATIVES AND USES THEREOF | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-09 | — | — | WO | claimed |
| US-6835744-B2 | For therapy of uterine myometrial fibroids, endometriosis, benign prostatic hypertrophy; carcinomas and adenocarcinomas of endometrium, ovary, breast, colon, prostate, pituitary, meningioma and other hormone-dependent tumors | WYETH | 2004-12-28 | — | — | US | disclosed |
| US-20020035099-A1 | Combination regimens using 3,3-substituted indoline derivatives | AMERICAN HOME PRODUCTS CORPORATION | 2002-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030008909-A1 | 3,3-substituted indoline derivatives | NR3C2, PGR, HTR3C | PGR 2/4885 |
| US-20020035099-A1 | Combination regimens using 3,3-substituted indoline derivatives | MC2R, PRLHR, MC5R | PGR 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.