SCHEMBL654142

SCHEMBL654142

CCCCOC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19116644 0.94 EPHX2 (0.89) EPHX2
SCHEMBL1060536 0.94 EPHX2 (1.00) EPHX2
SCHEMBL19116378 0.93 EPHX2 (0.87) EPHX2
SCHEMBL1065643 0.93 EPHX2 (1.00) EPHX2
SCHEMBL1061376 0.89 EPHX2 (1.00) EPHX2
SCHEMBL1066006 0.89 EPHX2 (1.00) EPHX2
SCHEMBL12931923 0.89 EPHX2 (1.00) EPHX2
SCHEMBL1065057 0.89 EPHX2 (1.00) EPHX2
SCHEMBL4009860 0.89 EPHX2 (1.00) EPHX2
SCHEMBL13651431 0.89 EPHX2 (1.00) EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 177 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230071934-A1 NOVEL USES INTRA-CELLULAR THERAPIES, INC. 2023-03-09 US claimed
WO-2021127517-A1 NOVEL USES INTRA-CELLULAR THERAPIES, INC. (US) 2021-06-24 WO claimed
US-20160256457-A1 METHODS FOR TREATING OR PREVENTING ACUTE VASCULAR LEAK NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2016-09-08 US claimed
EP-1904050-B1 USE OF CIS-EPOXYEICOSATRIENOIC ACIDS AND INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE TO REDUCE CARDIOMYOPATHY UNIV CALIFORNIA (US) 2012-11-14 EP claimed
US-8242170-B2 Use of cis-epoxyeicosatrienoic acids and inhibitors of soluble epoxide hydrolase to reduce cardiomyopathy THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-08-14 US claimed
US-20090216318-A1 Use of cis-epoxyeicosatrienoic acids and inhibitors of soluble epoxide hydrolase to reduce cardiomyopathy THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2009-08-27 US claimed
EP-1765311-A4 REDUCING NEPHROPATHY WITH INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE AND EPOXYEICOSANOIDS UNIV CALIFORNIA (US) 2009-04-29 EP claimed
US-20090018092-A1 Reducing Nephropathy with Inhibitors of Soluble Epoxide Hydrolase and Epoxyeicosanoids THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2009-01-15 US claimed
EP-1765311-A2 REDUCING NEPHROPATHY WITH INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE AND EPOXYEICOSANOIDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-03-28 EP claimed
EP-1737443-A2 USE OF CIS-EPOXYEICOSANTRIENOIC ACIDS AND INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE TO REDUCE PULMONARY INFILTRATION BY NEUTROPHILS The Regents of the University of California (US) 2007-01-03 EP claimed
WO-2005094373-A2 CIS-EPOXYEICOSANTRIENOIC ACIDS AND INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE AND METHODS TO REDUCE PULMONARY INFILTRATION BY NEUTROPHILS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2005-10-13 WO claimed
WO-2005089380-A2 REDUCING NEPHROPATHY WITH INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE AND EPOXYEICOSANOIDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2005-09-29 WO claimed
US-20260130877-A1 TREATMENT OF NEURODEVELOPMENTAL DISORDERS THE REGENTS OF THE UNIV OF CALIFORNIA (US) 2026-05-14 US disclosed
US-12357598-B2 Treatment of neurodevelopmental disorders THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-07-15 US disclosed
US-12251379-B2 Methods of inhibiting formation of alpha synuclein aggregates THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-03-18 US disclosed
US-20230301949-A1 TREATMENT OF NEURODEVELOPMENTAL DISORDERS CHIBA UNIVERSITY (JP) 2023-09-28 US disclosed
WO-2005089380-A2 REDUCING NEPHROPATHY WITH INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE AND EPOXYEICOSANOIDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2005-09-29 WO disclosed
US-20050164951-A1 Inhibitors for the soluble epoxide hydrolase THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2005-07-28 US disclosed
US-20050026844-A1 Inhibitors for the soluble epoxide hydrolase REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2005-02-03 US disclosed
WO-2004089296-A2 IMPROVED INHIBITORS FOR THE SOLUBLE EPOXIDE HYDROLASE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2004-10-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230301949-A1 TREATMENT OF NEURODEVELOPMENTAL DISORDERS FABP7, ADH1B, ELOVL1 EPHX2 51/4885
US-12357598-B2 Treatment of neurodevelopmental disorders FABP7, ADH1B, ELOVL1 EPHX2 51/4885
US-20050164951-A1 Inhibitors for the soluble epoxide hydrolase EPHX1, EPHX2, NCEH1 EPHX2 2/4885
US-20260130877-A1 TREATMENT OF NEURODEVELOPMENTAL DISORDERS EED, ICOS, FABP7 EPHX2 10/4885
US-12251379-B2 Methods of inhibiting formation of alpha synuclein aggregates SNCA, PARK7, PYGB EPHX2 3967/4885
US-20160256457-A1 METHODS FOR TREATING OR PREVENTING ACUTE VASCULAR LEAK BTK, ANTXR2, TBXA2R EPHX2 1640/4885
US-20090018092-A1 Reducing Nephropathy with Inhibitors of Soluble Epoxide Hydrolase and Epoxyeicosanoids EPHX1, EPHX2, NCEH1 EPHX2 2/4885
US-20230071934-A1 NOVEL USES SMPD1, PDE4A, PDE7A EPHX2 534/4885
US-20050026844-A1 Inhibitors for the soluble epoxide hydrolase EPHX1, EPHX2, NCEH1 EPHX2 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.