Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | BID | P55957 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6542674 | 0.92 | BCL2 (0.48) | BCL2BIDMCL1SRD5A2GAA | |
| SCHEMBL7644066 | 0.89 | BCL2 (0.50) | BCL2BIDMCL1SRD5A2GAA | |
| SCHEMBL6542672 | 0.80 | BCL2 (0.59) | BCL2BIDMCL1SRD5A2GAA | |
| SCHEMBL7641620 | 0.79 | MCL1 (0.52) | BCL2BIDMCL1SRD5A2ACLY | |
| SCHEMBL7638741 | 0.79 | BCL2 (0.49) | BCL2BIDMCL1SRD5A2ACLY | |
| SCHEMBL7638737 | 0.75 | BCL2 (0.59) | BCL2BIDMCL1SRD5A2ACLY | |
| SCHEMBL6543181 | 0.75 | MCL1 (0.59) | BCL2BIDMCL1SRD5A2ACLY | |
| SCHEMBL6598140 | 0.74 | CCR2 (0.54) | BCL2BIDMCL1SRD5A2PTGS2 | |
| SCHEMBL16486105 | 0.68 | NOD2 (0.58) | BCL2BIDMCL1ACLYPTGS2 | |
| SCHEMBL30411777 | 0.67 | NR1H4 (0.64) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6469046-B1 | FABH INHIBITORS WHICH ARE USEFUL AS ANTIBIOTICS FOR THE TREATMENT OF GRAM POSITIVE AND GRAM NEGATIVE BACTERIAL INFECTIONS | SMITHKLINE BEECHAM CORPORATION | 2002-10-22 | — | — | US | disclosed |