Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.49 |
| ▸ | BID | P55957 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | ACLY | P53396 | 7/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.37 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7641620 | 0.88 | MCL1 (0.52) | BCL2BIDMCL1ACLYSRD5A2 | |
| SCHEMBL7638737 | 0.87 | BCL2 (0.59) | BCL2BIDMCL1ACLYSRD5A2 | |
| SCHEMBL6542674 | 0.86 | BCL2 (0.48) | BCL2BIDMCL1ACLYSRD5A2 | |
| SCHEMBL6542672 | 0.83 | BCL2 (0.59) | BCL2BIDMCL1ACLYSRD5A2 | |
| SCHEMBL6543181 | 0.83 | MCL1 (0.59) | BCL2BIDMCL1ACLYSRD5A2 | |
| SCHEMBL7644069 | 0.79 | BCL2 (0.40) | BCL2BIDMCL1ACLYSRD5A2 | |
| SCHEMBL7644066 | 0.75 | BCL2 (0.50) | BCL2BIDMCL1SRD5A2CCR2 | |
| SCHEMBL7829429 | 0.73 | CCR2 (0.66) | BCL2BIDMCL1ACLYSRD5A2 | |
| SCHEMBL31159405 | 0.73 | BCL2 (0.66) | BCL2BIDMCL1SRD5A2CCR2 | |
| SCHEMBL4322740 | 0.69 | PLA2G4A (0.57) | MCL1SRD5A2CCR2LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6469046-B1 | FABH INHIBITORS WHICH ARE USEFUL AS ANTIBIOTICS FOR THE TREATMENT OF GRAM POSITIVE AND GRAM NEGATIVE BACTERIAL INFECTIONS | SMITHKLINE BEECHAM CORPORATION | 2002-10-22 | — | — | US | claimed |
| US-6469046-B1 | FABH INHIBITORS WHICH ARE USEFUL AS ANTIBIOTICS FOR THE TREATMENT OF GRAM POSITIVE AND GRAM NEGATIVE BACTERIAL INFECTIONS | SMITHKLINE BEECHAM CORPORATION | 2002-10-22 | — | — | US | disclosed |