Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CHUK | O15111 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | LTK | P29376 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | PRKX | P51817 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.31 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL824154 | 0.80 | ROCK2 (0.43) | ROCK2ROCK1LMNATDP1ALOX5 | |
| SCHEMBL1692318 | 0.80 | ROCK2 (0.43) | ROCK2ROCK1LMNATDP1ALOX5 | |
| SCHEMBL1227336 | 0.80 | ROCK2 (0.43) | ROCK2ROCK1LMNATDP1ALOX5 | |
| SCHEMBL11080452 | 0.80 | ROCK2 (0.43) | ROCK2ROCK1LMNATDP1ALOX5 | |
| SCHEMBL8072275 | 0.80 | ROCK2 (0.43) | ROCK2ROCK1LMNATDP1ALOX5 | |
| SCHEMBL10270877 | 0.80 | ROCK2 (0.43) | ROCK2ROCK1LMNATDP1ALOX5 | |
| SCHEMBL23812203 | 0.78 | ROCK2 (0.42) | ROCK2ROCK1LMNATDP1ALOX5 | |
| SCHEMBL1692266 | 0.78 | ROCK2 (0.42) | ROCK2ROCK1LMNATDP1ALOX5 | |
| Hydrochloric Acid SCHEMBL1692312 | 0.78 | ROCK2 (0.42) | ROCK2ROCK1LMNATDP1ALOX5 | |
| SCHEMBL659048 | 0.78 | ALOX5 (0.43) | ROCK2ROCK1LMNATDP1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135119-A4 | GLUCOSE AND LIPID LOWERING COMPOUNDS | ALTEON INC (US) | 2004-11-03 | — | — | EP | disclosed |
| US-6509480-B2 | 4,7,8 alpha H-eudesma-5(6), 11(13)-dien-8, 12-olide derivatives | ALTEON, INC. | 2003-01-21 | — | — | US | disclosed |
| US-20020151581-A1 | Glucose and lipid lowering compounds | SYNVISTA THERAPEUTICS, INC. | 2002-10-17 | — | — | US | disclosed |
| US-6326396-B1 | ACID OR AMIDE COMPOUND ON HYDRONAPHTHALENE COMPOUND | ALTEON, INC. | 2001-12-04 | — | — | US | disclosed |
| EP-1135119-A1 | GLUCOSE AND LIPID LOWERING COMPOUNDS | ALTEON, INC. (US) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000027388-A1 | GLUCOSE AND LIPID LOWERING COMPOUNDS | ALTEON, INC. (US) | 2000-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020151581-A1 | Glucose and lipid lowering compounds | HMGCR, APOB, SREBF1 | ROCK2 337/4885ROCK1 368/4885LMNA 1061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.