Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6544272 | 0.94 | MMP13 (0.38) | KDM4EMMP13BRD4ALDH1A1SMN1; SMN2 | |
| SCHEMBL6544430 | 0.92 | MMP13 (0.42) | FFAR1KDM4EMMP13ALDH1A1SMN1; SMN2 | |
| SCHEMBL6543839 | 0.88 | MAPT (0.40) | ALOX5KDM4EMMP13ALDH1A1SMN1; SMN2 | |
| SCHEMBL3487106 | 0.87 | HSD17B1 (0.44) | ALOX5KDM4EALDH1A1SMN1; SMN2HSD17B1 | |
| SCHEMBL4447092 | 0.86 | TBXA2R (0.42) | KDM4EMMP13ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4450704 | 0.86 | ALDH1A1 (0.48) | KDM4EMMP13ALDH1A1SMN1; SMN2NPY5R | |
| SCHEMBL6543697 | 0.86 | MAPT (0.38) | FFAR1KDM4EMMP13BRD4ALDH1A1 | |
| SCHEMBL27782513 | 0.86 | SIRT5 (0.42) | KDM4EMMP13ALDH1A1SMN1; SMN2 | |
| SCHEMBL6544703 | 0.86 | PDCD1 (0.36) | FFAR4KDM4EBRD4ALDH1A1SMN1; SMN2 | |
| SCHEMBL6544794 | 0.85 | BCL2 (0.43) | ALDH1A1BCL2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1022272-B1 | SUBSTITUTED FUSED HETEROCYCLIC COMPOUNDS | SANKYO CO (JP) | 2004-05-26 | — | — | EP | disclosed |
| US-6432993-B1 | BENZIMIDAZOLE OR IMIDAZO(4,5-B)PYRIDINE DERIVATES; IMMUNOMODULATORS; ALDOSE REDUCTASE AND LIPOXYGENASE INHIBITORS; DIABETES; PREVENTS LIPID PEROXIDATION; ANTILIPEMIC, HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 2002-08-13 | — | — | US | disclosed |
| EP-1022272-A1 | SUBSTITUTED FUSED HETEROCYCLIC COMPOUNDS | Sankyo Company Limited (JP) | 2000-07-26 | — | — | EP | disclosed |