Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.52 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8736122 | 0.95 | AGTR1 (0.47) | AGTR1AGTR2 | |
| SCHEMBL6545554 | 0.94 | AGTR1 (0.57) | AGTR1AGTR2 | |
| SCHEMBL3840808 | 0.92 | AGTR1 (0.57) | AGTR1AGTR2 | |
| SCHEMBL6546048 | 0.88 | AGTR1 (0.48) | AGTR1AGTR2PPARG | |
| SCHEMBL6545316 | 0.88 | AGTR1 (0.49) | AGTR1AGTR2 | |
| SCHEMBL186 | 0.87 | AGTR1 (0.65) | AGTR1AGTR2 | |
| SCHEMBL7443225 | 0.87 | AGTR1 (0.51) | AGTR1AGTR2 | |
| SCHEMBL7907438 | 0.85 | AGTR1 (0.47) | AGTR1AGTR2 | |
| SCHEMBL287 | 0.85 | AGTR1 (0.51) | AGTR1AGTR2 | |
| SCHEMBL62 | 0.83 | AGTR1 (0.73) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019048-B1 | USE OF AN ANGIOTENSIN II RECEPTOR ANTAGONIST FOR THE PREPARATION OF DRUGS TO INCREASE THE SURVIVAL RATE OF RENAL TRANSPLANT PATIENTS | MERCK SHARP DOHME ITALIA S P A (IT) | 2004-01-21 | — | — | EP | claimed |
| EP-0733366-B1 | Pharmaceutical compositions comprising angiotensin II receptor blocking imidazoles and diuretics | DU PONT (US) | 1998-04-01 | — | — | EP | claimed |
| EP-0533840-B1 | TREATMENT OF CHRONIC RENAL FAILURE WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS | DU PONT (US) | 1996-12-11 | — | — | EP | claimed |