Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | RAPGEF3 | O95398 | 9/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4461300 | 0.81 | L3MBTL1 (0.50) | HSD17B10ESR2L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL15022277 | 0.81 | LMNA (0.50) | HSD17B10ESR2L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL838079 | 0.80 | L3MBTL1 (0.52) | HSD17B10ESR2L3MBTL1ALDH1A1TSHR | |
| SCHEMBL6619666 | 0.78 | ALDH1A1 (0.44) | HSD17B10ALDH1A1TSHRKIF11KDM4E | |
| SCHEMBL14519387 | 0.77 | L3MBTL1 (0.49) | HSD17B10ESR2L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL27792575 | 0.77 | NR1H4 (0.44) | HSD17B10ALDH1A1TSHRKIF11RAPGEF3 | |
| Bromide SCHEMBL6545831 | 0.77 | ALDH1A1 (0.43) | HSD17B10ALDH1A1TSHRKIF11KDM4E | |
| SCHEMBL6176444 | 0.75 | LTA4H (0.50) | HSD17B10ESR2L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL5256232 | 0.75 | L3MBTL1 (0.47) | HSD17B10ESR2L3MBTL1ALDH1A1TSHR | |
| SCHEMBL8836254 | 0.74 | HSD17B10 (0.47) | HSD17B10ESR2L3MBTL1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027050-B1 | 1,3-THIAZOLES AS ADENOSINE A3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ALLERGY, ASTHMA AND DIABETES | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-01-14 | — | — | EP | disclosed |
| US-6620825-B1 | 1,3-Azole compound substituted by pyridyl; administering as antiasthmatic, antiinflammatory or antiallergen agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-09-16 | — | — | US | disclosed |
| US-6436966-B1 | Adenosine A3 receptor antagonists | TAKEDA CHEMICAL IND., LTD. (JP) | 2002-08-20 | — | — | US | disclosed |
| EP-1027050-A2 | ADENOSINE A3 RECEPTOR ANTAGONISTS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999021555-A2 | ADENOSINE A3 RECEPTOR ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-05-06 | — | — | WO | disclosed |