Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.46 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL2355578 | 0.92 | MEN1 (0.55) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Fumaric Acid SCHEMBL2352041 | 0.92 | MEN1 (0.55) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Fumaric Acid SCHEMBL2352047 | 0.92 | MEN1 (0.55) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Fumaric Acid SCHEMBL17894109 | 0.90 | CYP3A4 (0.59) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Fumaric Acid SCHEMBL7046688 | 0.90 | MEN1 (0.52) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Fumaric Acid SCHEMBL7046696 | 0.90 | MEN1 (0.52) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Fumaric Acid SCHEMBL2352045 | 0.89 | LMNA (0.57) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Maleic Acid SCHEMBL2355580 | 0.89 | LMNA (0.57) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Maleic Acid SCHEMBL9229485 | 0.89 | LMNA (0.57) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Fumaric Acid SCHEMBL27141144 | 0.89 | LMNA (0.57) | MEN1LMNAKMT2ACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3964258-B1 | A DRY STIMULATION ELECTRODE | HENKEL AG & CO KGAA (DE) | 2024-11-06 | — | — | EP | claimed |
| CN-113543706-B | Electrode comprising a conductive acrylate-based pressure sensitive adhesive | 汉高股份有限及两合公司 | 2024-07-23 | — | — | CN | claimed |
| WO-2024040141-A1 | COMPOSITION OF MATTER, SYSTEM, AND METHOD FOR ENHANCED MAGNESIUM UPTAKE, RETENTION, AND SYNERGISTIC ACTIONS | RMJ HOLDINGS, LLC (US) | 2024-02-22 | — | — | WO | claimed |
| US-20240058376-A1 | COMPOSITION OF MATTER, SYSTEM, AND METHOD FOR ENHANCED MAGNESIUM UPTAKE, RETENTION, AND SYNERGISTIC ACTIONS | RMJH Holdings, LLC (US) | 2024-02-22 | — | — | US | claimed |
| EP-3935119-B1 | DRY ELECTRODE ADHESIVE | HENKEL AG & CO KGAA (DE) | 2024-01-24 | — | — | EP | claimed |
| US-11712449-B1 | Composition of matter, system, and method for enhanced magnesium uptake, retention, and synergistic actions | RMJH Holdings, LLC (US) | 2023-08-01 | — | — | US | claimed |
| US-20230200703-A1 | Dry Stimulating electrode | HENKEL AG & CO KGAA (DE) | 2023-06-29 | — | — | US | claimed |
| CN-115989294-A | Dry stimulating electrode | 汉高股份有限及两合公司 | 2023-04-18 | — | — | CN | claimed |
| CN-114044852-B | Polymerizable eutectic solvent, conductive elastomer and preparation method of conductive elastomer | 江南大学 | 2022-11-22 | — | — | CN | claimed |
| US-20220098454-A1 | DRY ELECTRODE ADHESIVE | HENKEL AG & CO. KGAA (DE) | 2022-03-31 | — | — | US | claimed |
| EP-3964258-A1 | A DRY STIMULATION ELECTRODE | Henkel AG & Co. KGaA (DE) | 2022-03-09 | — | — | EP | claimed |
| CN-114044852-A | Polymerizable eutectic solvent, conductive elastomer and preparation method thereof | 江南大学 | 2022-02-15 | — | — | CN | claimed |
| EP-3935119-A1 | DRY ELECTRODE ADHESIVE | Henkel AG & Co. KGaA (DE) | 2022-01-12 | — | — | EP | claimed |
| EP-3934524-A1 | ELECTRODE COMPRISING A CONDUCTIVE ACRYLATE BASED PRESSURE SENSITIVE ADHESIVE | Henkel AG & Co. KGaA (DE) | 2022-01-12 | — | — | EP | claimed |
| US-20210386379-A1 | ELECTRODE COMPRISING A CONDUCTIVE ACRYLATE BASED PRESSURE SENSITIVE ADHESIVE | HENKEL AG & CO KGAA (DE) | 2021-12-16 | — | — | US | claimed |
| CN-113557281-A | Dry electrode binder | 汉高股份有限及两合公司 | 2021-10-26 | — | — | CN | claimed |
| CN-113543706-A | Electrode comprising a conductive acrylate-based pressure sensitive adhesive | 汉高股份有限及两合公司 | 2021-10-22 | — | — | CN | claimed |
| EP-1381285-A1 | A RUMEN BYPASS COMPOSITION CONTAINING A BIOACTIVE SUBSTANCE AND A METHOD FOR ITS PREPARATION | Jubilant Organosys Limited (IN) | 2004-01-21 | — | — | EP | claimed |
| WO-2002082921-A1 | A RUMEN BYPASS COMPOSITION CONTAINING A BIOACTIVE SUBSTANCE AND A METHOD FOR ITS PREPARATION | JUBILANT ORGANOSYS LIMITED (IN) | 2002-10-24 | — | — | WO | claimed |
| US-4948589-A | CHOLINE COATED WITH HYDROPHOBIC FILM FOR DELAYED DISSOLVING | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1990-08-14 | — | — | US | claimed |