Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EEF2K | O00418 | 1/20 | 0.57 |
| ▸ | PLK4 | O00444 | 1/20 | 0.57 |
| ▸ | IKBKB | O14920 | 1/20 | 0.57 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.57 |
| ▸ | CDK2 | P24941 | 1/20 | 0.57 |
| ▸ | AKT1 | P31749 | 1/20 | 0.57 |
| ▸ | AKT2 | P31751 | 1/20 | 0.57 |
| ▸ | CLK2 | P49760 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.57 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.57 |
| ▸ | NEK4 | P51957 | 1/20 | 0.57 |
| ▸ | PLK1 | P53350 | 1/20 | 0.57 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.57 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.57 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.57 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.57 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.57 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6545665 | 0.90 | EEF2K (0.71) | EEF2KPLK4IKBKBDYRK3PIM1 | |
| SCHEMBL8475832 | 0.83 | PIM1 (0.51) | EEF2KPLK4IKBKBDYRK3PIM1 | |
| SCHEMBL6545791 | 0.80 | EEF2K (0.57) | EEF2KPLK4IKBKBDYRK3PIM1 | |
| SCHEMBL8784156 | 0.79 | CYP1A2 (0.56) | CYP2C9 | |
| SCHEMBL8784457 | 0.78 | CYP1A2 (0.58) | CYP2C9 | |
| SCHEMBL8480479 | 0.74 | CYP2C9 (0.49) | EEF2KPLK4IKBKBDYRK3PIM1 | |
| SCHEMBL7455746 | 0.73 | TUBB4A (0.48) | EEF2KPLK4IKBKBDYRK3PIM1 | |
| SCHEMBL6545590 | 0.73 | EEF2K (1.00) | EEF2KPLK4IKBKBDYRK3PIM1 | |
| SCHEMBL8482604 | 0.71 | CYP2C9 (0.51) | PIM1CDK2CLK2GSK3BCAMK2B | |
| SCHEMBL8475992 | 0.71 | ROCK2 (0.53) | PIM1CDK2CLK2GSK3BCAMK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942723-B1 | 4-ARYL-3-HYDROXYQUINOLIN-2-ONE DERIVATIVES AS ION CHANNEL MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2004-01-21 | — | — | EP | disclosed |
| EP-0942723-A4 | 4-ARYL-3-HYDROXYQUINOLIN-2-ONE DERIVATIVES AS ION CHANNEL MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2002-05-15 | — | — | EP | disclosed |
| EP-0942723-A1 | 4-ARYL-3-HYDROXYQUINOLIN-2-ONE DERIVATIVES AS ION CHANNEL MODULATORS | Bristol-Myers Squibb Company (US) | 1999-09-22 | — | — | EP | disclosed |
| US-5922735-A | CALCIUM-ACTIVATED POTASSIUM CHANNELS AND ARE USEFUL TREATING THE DISORDER RESPONSIVE TO THE OPENING OF THE POTASSIUM CHANNELS SUCH AS ISCHEMIA, CONVULSIONS, ASTHMA, IRRITABLE BOWEL SYNDROME, MIGRAINE, TRAUMATIC BRAIN INJURY | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-07-13 | — | — | US | disclosed |
| US-5908495-A | COLORANT; A MODIFIED PHOTOREACTOR; AND A LIQUID VEHICLE WHEREIN THE COLORANT IS RENDERED LIGHT-STABLE IN THE MIXTURE | NOHR RONALD SINCLAIR (US) | 1999-06-01 | — | — | US | disclosed |
| US-5892045-A | 4-aryl-3-hydroxyquinolin-2-one derivatives as ion channel modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-04-06 | — | — | US | disclosed |
| WO-1998023273-A1 | 4-ARYL-3-HYDROXYQUINOLIN-2-ONE DERIVATIVES AS ION CHANNEL MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-06-04 | — | — | WO | disclosed |