Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6545799 | 0.86 | KMT2A (0.52) | KMT2AALDH1A1PTGS2KDM4EHPGD | |
| SCHEMBL6545480 | 0.86 | L3MBTL1 (0.41) | KMT2AALDH1A1PTGS2KDM4EHPGD | |
| SCHEMBL6545699 | 0.83 | KMT2A (0.54) | KMT2AALDH1A1PTGS2KDM4EHPGD | |
| SCHEMBL6546638 | 0.83 | L3MBTL1 (0.45) | KMT2AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL6546817 | 0.73 | KMT2A (0.47) | KMT2AALDH1A1PTGS2KDM4EHPGD | |
| SCHEMBL6284661 | 0.73 | KDM4E (0.59) | KMT2AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL15269254 | 0.72 | PTGS2 (0.57) | ALDH1A1PTGS2KDM4EPTGS1HTT | |
| SCHEMBL6545818 | 0.72 | PRKCI (0.43) | KMT2AALDH1A1PTGS2KDM4EHPGD | |
| SCHEMBL7844066 | 0.71 | PTGS2 (0.59) | KMT2AALDH1A1PTGS2KDM4EMAPT | |
| SCHEMBL9548086 | 0.70 | KMT2A (1.00) | KMT2AALDH1A1PTGS2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027050-B1 | 1,3-THIAZOLES AS ADENOSINE A3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ALLERGY, ASTHMA AND DIABETES | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-01-14 | — | — | EP | disclosed |
| US-6620825-B1 | 1,3-Azole compound substituted by pyridyl; administering as antiasthmatic, antiinflammatory or antiallergen agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-09-16 | — | — | US | disclosed |
| US-6436966-B1 | Adenosine A3 receptor antagonists | TAKEDA CHEMICAL IND., LTD. (JP) | 2002-08-20 | — | — | US | disclosed |