Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 2/20 | 0.43 |
| ▸ | EP300 | Q09472 | 2/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | FBP1 | P09467 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6546712 | 0.94 | EP300 (0.43) | PRKCIEP300KIF11GCGRKMT2A | |
| SCHEMBL6545799 | 0.86 | KMT2A (0.52) | GCGRKMT2AHPGDALDH1A1HSD17B10 | |
| SCHEMBL6545480 | 0.86 | L3MBTL1 (0.41) | PRKCIEP300KIF11GCGRKMT2A | |
| SCHEMBL6545710 | 0.83 | ADORA3 (0.41) | PRKCIHPGDALDH1A1HSD17B10KDM4E | |
| SCHEMBL6545699 | 0.79 | KMT2A (0.54) | GCGRKMT2AHPGDALDH1A1HSD17B10 | |
| SCHEMBL6546200 | 0.76 | KIF11 (0.41) | PRKCIEP300KIF11GCGRKMT2A | |
| SCHEMBL6546319 | 0.76 | ADORA3 (0.43) | KMT2AHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL6279799 | 0.72 | MAPT (0.58) | EP300KIF11GCGRKMT2AHPGD | |
| SCHEMBL6545946 | 0.72 | MAPT (0.58) | EP300KIF11GCGRKMT2AHPGD | |
| SCHEMBL6546266 | 0.72 | KMT2A (0.53) | GCGRKMT2AHPGDALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027050-B1 | 1,3-THIAZOLES AS ADENOSINE A3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ALLERGY, ASTHMA AND DIABETES | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-01-14 | — | — | EP | disclosed |
| US-6620825-B1 | 1,3-Azole compound substituted by pyridyl; administering as antiasthmatic, antiinflammatory or antiallergen agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-09-16 | — | — | US | disclosed |
| US-6436966-B1 | Adenosine A3 receptor antagonists | TAKEDA CHEMICAL IND., LTD. (JP) | 2002-08-20 | — | — | US | disclosed |