Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | FDPS | P14324 | 1/20 | 0.53 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | FABP1 | P07148 | 1/20 | 0.49 |
| ▸ | FABP6 | P51161 | 1/20 | 0.49 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10830140 | 0.84 | CYP2D6 (0.53) | CYP2D6FDPSCXCR4CYP2C19FABP1 | |
| SCHEMBL7448193 | 0.79 | CYP2D6 (0.59) | CYP2D6FDPSCXCR4CYP2C19FABP1 | |
| SCHEMBL17700255 | 0.79 | CYP2D6 (0.48) | CYP2D6FDPSCXCR4CYP2C19FABP1 | |
| SCHEMBL4281005 | 0.78 | CYP2D6 (0.72) | CYP2D6FDPSCXCR4CYP2C19FABP1 | |
| SCHEMBL1831588 | 0.76 | CYP2D6 (0.56) | CYP2D6FDPSCXCR4CYP2C19FABP1 | |
| SCHEMBL5845328 | 0.76 | CYP2D6 (0.65) | CYP2D6FDPSCXCR4CYP2C19FABP1 | |
| SCHEMBL6800071 | 0.76 | CYP2D6 (0.65) | CYP2D6FDPSCXCR4CYP2C19FABP1 | |
| SCHEMBL14198659 | 0.76 | CYP2D6 (0.56) | CYP2D6FDPSCXCR4CYP2C19FABP1 | |
| SCHEMBL19935946 | 0.76 | CYP2D6 (0.56) | CYP2D6FDPSCXCR4CYP2C19FABP1 | |
| SCHEMBL13753840 | 0.76 | FDPS (0.54) | CYP2D6FDPSCXCR4CYP2C19FABP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906100-B1 | USE OF 5-HT 1A? RECEPTOR ANTAGONISTS FOR THE TREATMENT OF URINARY INCONTINENCE | RECORDATI CHEM PHARM (CH) | 2004-01-28 | — | — | EP | disclosed |
| US-6271234-B1 | DERIVATIVES WHICH BIND TO SEROTONERGIC RECEPTORS; TREATING DISORDERS OF THE LOWER URINARY TRACT | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2001-08-07 | — | — | US | disclosed |
| EP-1000045-A1 | 1,4-DISUBSTITUTED PIPERAZINES | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 2000-05-17 | — | — | EP | disclosed |
| US-5990114-A | ADMINISTERING 1,4-SUBSTITUTED PIPERAZINE DERIVATIVES OF GIVEN FORMULA TO TREAT NEUROMUSCULAR DYSFUNCTION OF THE LOWER URINARY TRACT; BOTH PRE- AND POST-SYNAPTIC ANTAGONISM; SUCH AS 1-(2-((2-PYRIDYLAMINO)ETHYL)-4-(4-INDOLYL)PIPERAZINE | RECORDATI, S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1999-11-23 | — | — | US | disclosed |
| EP-0906100-A1 | USE OF 5-HT 1A? RECEPTOR ANTAGONISTS FOR THE TREATMENT OF URINARY INCONTINENCE | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1999-04-07 | — | — | EP | disclosed |
| WO-1999006382-A1 | 1,4-DISUBSTITUTED PIPERAZINES | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1999-02-11 | — | — | WO | disclosed |
| WO-1997031637-A1 | USE OF 5-HT1A RECEPTOR ANTAGONISTS FOR THE TREATMENT OF URINARY INCONTINENCE | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1997-09-04 | — | — | WO | disclosed |