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Arginine

Arginine

SCHEMBL6546431

CC(C)C[C@H](N)C(=O)O.CC(C)C[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O.NC(=O)CC[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NCC(=O)O.NCC(=O)OC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.N[C@@H](CC(=O)O)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O.O=C(O)[C@@H]1CCCN1.O=C(O)[C@@H]1CCCN1.O=C(O)[C@@H]1CCCN1

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ GHSR Q92847 4/20 0.36
▸ MC4R P32245 1/20 0.34
▸ KDM1A O60341 2/20 0.34
▸ MAOB P27338 1/20 0.34
▸ KDM5A P29375 1/20 0.34
▸ KDM1B Q8NB78 1/20 0.34
▸ GLP1R P43220 7/20 0.33
▸ APLNR P35414 1/20 0.32
▸ VIPR2 P41587 1/20 0.32
▸ KEAP1 Q14145 1/20 0.32
▸ NPY1R P25929 1/20 0.32
▸ NPY2R P49146 1/20 0.32
▸ NPY4R P50391 1/20 0.32
▸ NPY5R Q15761 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Arginine SCHEMBL28079278 0.85 TUBB4A (0.33) —
Cystine SCHEMBL9697229 0.85 CALCR (0.37) MC4RAPLNRKEAP1
Arginine SCHEMBL6481630 0.85 GLP1R (0.35) MC4RGLP1RVIPR2
Arginine SCHEMBL28484320 0.84 VIPR2 (0.36) GLP1RVIPR2
Arginine SCHEMBL27538187 0.84 TUBB4A (0.38) MC4RAPLNR
Arginine SCHEMBL6040161 0.84 TUBB4A (0.34) GHSRMC4RKDM1AMAOBKDM5A
Tryptophan SCHEMBL27501971 0.84 GLP1R (0.41) GLP1R
Arginine SCHEMBL21569401 0.83 KDM1A (0.34) MC4RKDM1AMAOBKDM5AKDM1B
Arginine SCHEMBL9164072 0.83 KDM1A (0.35) KDM1AMAOBKDM5AKDM1BVIPR2
Arginine SCHEMBL8073440 0.83 MC4R (0.34) GHSRMC4RKDM1AMAOBKDM5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0767381-B1 Detection, quantification and classification of ras proteins in body fluids and tissues BAYER AG (US) 2004-01-28 — — EP disclosed
US-6200764-B1 MONITORING ACTIVATED G-PROTEIN IN A BODILY FLUID; INCUBATING BODILY FLUID WITH AN IMMOBILIZED MONOCOLNAL ANTIBODY, SCREEN FOR SIGNAL IN SAMPLE BAYER CORPORATION 2001-03-13 — — US disclosed
EP-0411018-B1 DETECTION, QUANTITATION AND CLASSIFICATION OF RAS PROTEINS IN BODY FLUIDS AND TISSUES ONCOGENE SCIENCE INC (US) 1997-06-04 — — EP disclosed
EP-0767381-A1 Detection, quantification and classification of ras proteins in body fluids and tissues Oncogene Science, Inc. (US) 1997-04-09 — — EP disclosed