Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.34 |
| ▸ | TUBB | P07437 | 2/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.34 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.34 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.34 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.34 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.34 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.34 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.34 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.33 |
| ▸ | APLNR | P35414 | 3/20 | 0.33 |
| ▸ | KDM1A | O60341 | 3/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL6040161 | 0.99 | TUBB4A (0.34) | MC4RTUBB4ATUBBTUBA3CTUBA1B | |
| Arginine SCHEMBL28079278 | 0.93 | TUBB4A (0.33) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Histidine SCHEMBL7759763 | 0.90 | GSR (0.32) | GHSR | |
| Arginine SCHEMBL27447445 | 0.89 | TUBB4A (0.35) | MC4RTUBB4ATUBBTUBA3CTUBA1B | |
| Arginine SCHEMBL18042243 | 0.87 | MC4R (0.33) | MC4RTUBB4ATUBBTUBA3CTUBA1B | |
| Arginine SCHEMBL27510584 | 0.87 | APLNR (0.33) | APLNRMAPK8MAPK9MAPK10 | |
| Histidine SCHEMBL8428516 | 0.87 | GHSR (0.30) | GHSR | |
| Arginine SCHEMBL27090217 | 0.87 | TUBB4A (0.36) | MC4RTUBB4ATUBBTUBA3CTUBA1B | |
| Histidine SCHEMBL7757156 | 0.87 | — | — | |
| Arginine SCHEMBL28048007 | 0.86 | KDM1A (0.34) | MC4RTUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019727-A1 | IMMUNOASSAY FOR THE DETECTION OF CANCER | AMDL, INC (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1998055872-A1 | IMMUNOASSAY FOR THE DETECTION OF CANCER | AMDL, INC. (US) | 1998-12-10 | — | — | WO | disclosed |