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Arginine

Arginine

SCHEMBL28079278

CCC(C)C(N)C(=O)O.N=C(N)NCCCC(N)C(=O)O.NC(CC(=O)O)C(=O)O.NC(CS)C(=O)O.NC(Cc1c[nH]cn1)C(=O)O.NCCCCC(N)C(=O)O.O=C(O)[C@@H]1CCCN1

nearest known ligand 0.33

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACES1PR1S1PR4S1PR5

The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TUBB4A P04350 2/20 0.33
▸ TUBB P07437 2/20 0.33
▸ TUBA3C P0DPH7 2/20 0.33
▸ TUBA1B P68363 2/20 0.33
▸ TUBA4A P68366 2/20 0.33
▸ TUBB4B P68371 2/20 0.33
▸ TUBB3 Q13509 2/20 0.33
▸ TUBB2A Q13885 2/20 0.33
▸ TUBB8 Q3ZCM7 2/20 0.33
▸ TUBA3E Q6PEY2 2/20 0.33
▸ TUBA1A Q71U36 2/20 0.33
▸ TUBA1C Q9BQE3 2/20 0.33
▸ TUBB6 Q9BUF5 2/20 0.33
▸ TUBB2B Q9BVA1 2/20 0.33
▸ TUBB1 Q9H4B7 2/20 0.33
▸ C5AR1 P21730 1/20 0.31
▸ MAPK8 P45983 1/20 0.31
▸ MAPK9 P45984 1/20 0.31
▸ MAPK10 P53779 1/20 0.31
▸ NFE2L2 Q16236 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Arginine SCHEMBL8073440 0.93 MC4R (0.34) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Arginine SCHEMBL6040161 0.91 TUBB4A (0.34) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Arginine SCHEMBL27510584 0.90 APLNR (0.33) MAPK8MAPK9MAPK10
Arginine SCHEMBL27538187 0.88 TUBB4A (0.38) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Arginine SCHEMBL27090217 0.87 TUBB4A (0.36) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Arginine SCHEMBL27447445 0.87 TUBB4A (0.35) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Histidine SCHEMBL29169735 0.85 HCRTR1 (0.30) —
Arginine SCHEMBL6546431 0.85 GHSR (0.36) —
Arginine SCHEMBL8995772 0.84 NPY4R (0.32) —
Arginine SCHEMBL27486899 0.84 NPY4R (0.32) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105765067-A Modified beta-galactosidase 天野酶株式会社 2016-07-13 — — CN claimed
CN-105765067-A Modified beta-galactosidase 天野酶株式会社 2016-07-13 — — CN disclosed