SCHEMBL6548740

SCHEMBL6548740

ON=C(COc1c(Cl)cc(OCC=C(Cl)Cl)cc1Cl)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 2/20 0.42
GAA P10253 1/20 0.37
LMNA P02545 1/20 0.33
MAPT P10636 1/20 0.33
KMT2A Q03164 2/20 0.33
HTT P42858 1/20 0.33
CYP26A1 O43174 2/20 0.30
CYP3A4 P08684 1/20 0.30
CYP26B1 Q9NR63 1/20 0.30
DRD4 P21917 1/20 0.30
PLAU P00749 1/20 0.30
MEN1 O00255 1/20 0.30
NPC1 O15118 1/20 0.30
POLB P06746 1/20 0.30
RAB9A P51151 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6548269 0.88 LMNA (0.36) SLC6A4LMNAMAPTKMT2AHTT
SCHEMBL6548225 0.84 SLC6A4 (0.35) SLC6A4LMNAMAPTHTT
SCHEMBL6548447 0.82 L3MBTL1 (0.42) LMNAMAPTKMT2AHTTMEN1
SCHEMBL6549758 0.78 MAPT (0.43) SLC6A4GAALMNAMAPTKMT2A
SCHEMBL6548606 0.78 MAPT (0.43) SLC6A4GAALMNAMAPTKMT2A
SCHEMBL6547982 0.78 HTT (0.39) HTT
SCHEMBL6548509 0.78 MAPT (0.42) SLC6A4GAALMNAMAPTKMT2A
SCHEMBL8407690 0.77 HTT (0.41) HTTPLAU
SCHEMBL8657700 0.77 HTT (0.40) KMT2AHTTDRD4PLAUMEN1
SCHEMBL8408601 0.77 KDM4E (0.41) GAALMNAMAPTKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0975586-B1 OXIME COMPOUNDS, THEIR USE, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL CO (JP) 2004-12-01 EP disclosed
US-6448444-B2 INSECTICIDES, MITICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-09-10 US disclosed
US-6437184-B1 INSECTICIDES, ACARICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-08-20 US disclosed
US-20020019569-A1 Oxime compounds, their use, and intermediates for their production SUMITOMO CHEMICAL COMPANY, LIMITED 2002-02-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020019569-A1 Oxime compounds, their use, and intermediates for their production CBR3, CBR1, NOX3 SLC6A4 4778/4885GAA 3855/4885LMNA 3205/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.