Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 5/20 | 0.43 |
| ▸ | RARB | P10826 | 5/20 | 0.43 |
| ▸ | RARG | P13631 | 5/20 | 0.43 |
| ▸ | PLAU | P00749 | 7/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | PLAT | P00750 | 2/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | PTPRF | P10586 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6908997 | 0.89 | RARA (0.54) | RARARARBRARGPGR | |
| SCHEMBL6907265 | 0.83 | RARB (0.64) | RARARARBRARGPLAUEGFR | |
| SCHEMBL31298127 | 0.75 | EGFR (0.60) | PLAUEGFRMAPK14PTPN1HSD17B2 | |
| SCHEMBL6138470 | 0.75 | EGFR (0.60) | PLAUEGFRMAPK14PTPN1HSD17B2 | |
| SCHEMBL8437231 | 0.70 | RARB (0.66) | RARARARBRARGPLAUCYP11B1 | |
| SCHEMBL8438543 | 0.69 | RARB (0.54) | RARARARBRARGPLAUEGFR | |
| SCHEMBL8438952 | 0.69 | RARB (0.56) | RARARARBRARGPLAUEGFR | |
| SCHEMBL8709650 | 0.68 | CYP11B2 (0.58) | RARARARBRARGCYP19A1CYP11B1 | |
| SCHEMBL28189889 | 0.67 | EGFR (0.68) | PLAUEGFRPLATPLGCYP19A1 | |
| SCHEMBL8709424 | 0.66 | RARB (0.63) | RARARARBRARGHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040122080-A1 | Synergist combinations of retinoid receptor ligands and selected cytotoxic agents for treatment of cancer | BRISTOL-MYERS SQUIBB COMPANY | 2004-06-24 | — | — | US | disclosed |
| EP-1383491-A2 | SYNERGISTIC COMBINATIONS OF RETINOID RECEPTOR LIGANDS AND SELECTED CYTOTOXIC AGENTS FOR TREATMENT OF CANCER | Bristol-Myers Squibb Company (US) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002078620-A2 | SYNERGISTIC COMBINATIONS OF RETINOID RECEPTOR LIGANDS AND SELECTED CYTOTOXIC AGENTS FOR TREATMENT OF CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122080-A1 | Synergist combinations of retinoid receptor ligands and selected cytotoxic agents for treatment of cancer | RARA, RARG, RARB | RARA 1/4885RARB 3/4885RARG 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.