Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 10/20 | 0.54 |
| ▸ | RARG | P13631 | 10/20 | 0.54 |
| ▸ | RARA | P10276 | 9/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.40 |
| ▸ | PLAU | P00749 | 2/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8436552 | 0.81 | RARB (0.55) | RARBRARGRARACYP3A4EGFR | |
| SCHEMBL6292717 | 0.79 | CYP3A4 (0.48) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL8713153 | 0.76 | GSTP1 (0.43) | RARBRARGRARACYP3A4 | |
| SCHEMBL6423981 | 0.76 | RARB (0.68) | RARBRARGRARACYP26A1 | |
| SCHEMBL8437231 | 0.76 | RARB (0.66) | RARBRARGRARACYP11B1CYP11B2 | |
| SCHEMBL6294335 | 0.76 | RARA (0.48) | RARBRARGRARACYP26A1SLC6A2 | |
| SCHEMBL6814372 | 0.75 | RXRA (0.49) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL8705923 | 0.75 | RARA (0.51) | RARBRARGRARACYP3A4EGFR | |
| SCHEMBL8688333 | 0.74 | RARG (0.56) | RARBRARGRARACYP3A4CYP11B1 | |
| SCHEMBL18775432 | 0.74 | RARB (0.73) | RARBRARGRARACYP3A4CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5945561-A | ANTIINFLAMMATORY AGENT, RHEUMATIC DISORDERS, SKIN DISORDERS,ANTISCARRING AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-08-31 | — | — | US | disclosed |
| WO-1998049136-A1 | RETINOID-LIKE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-11-05 | — | — | WO | disclosed |