Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6885649 | 1.00 | PSEN1 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6548680 | 0.79 | REN (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6884561 | 0.75 | METAP2 (0.35) | KCNA5RENALDH1A1TACR1 | |
| SCHEMBL17803300 | 0.69 | REN (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22006160 | 0.69 | REN (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6550961 | 0.68 | TACR1 (0.34) | RENALDH1A1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL18615761 | 0.65 | NAAA (0.54) | KCNA5REN | |
| SCHEMBL22588318 | 0.64 | REN (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22454181 | 0.64 | NAAA (0.56) | KCNA5CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4525509 | 0.64 | GAA (0.47) | HCRTR1HCRTR2ALDH1A1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480964-A1 | INHIBITEURS DE L'ANGIOGENESE | Galderma Research & Development, S.N.C. (FR) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003040119-A1 | ANGIOGENESIS INHIBITORS | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2003-05-15 | — | — | WO | disclosed |