Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Dimethylformamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ADH1C | P00326 | 1/20 | 0.31 |
| ▸ | ADH1A | P07327 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL28212755 | 0.96 | TSHR (0.39) | TSHRALDH1A1SMN1; SMN2FFAR3LCK | |
| Tetrahydrofuran SCHEMBL23295002 | 0.91 | TSHR (0.43) | TSHRALDH1A1SMN1; SMN2 | |
| Dioxane SCHEMBL6550359 | 0.89 | TSHR (0.45) | TSHRSMN1; SMN2FFAR3LCKFYN | |
| Dimethylformamide SCHEMBL1072443 | 0.89 | TSHR (0.50) | TSHRALDH1A1ADH1CADH1A | |
| Tetrahydrofuran SCHEMBL9439653 | 0.87 | TSHR (0.39) | TSHRALDH1A1SMN1; SMN2 | |
| Tetrahydrofuran SCHEMBL2439396 | 0.86 | TSHR (0.47) | TSHRALDH1A1ADH1CADH1A | |
| Tetrahydrofuran SCHEMBL129722 | 0.86 | TSHR (0.53) | TSHRALDH1A1ADH1CADH1A | |
| Tetrahydrofuran SCHEMBL28743802 | 0.84 | TSHR (0.50) | TSHRALDH1A1ADH1CADH1A | |
| Acetic Acid SCHEMBL575053 | 0.83 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2FFAR3LCKFYN | |
| Acetic Acid SCHEMBL29037898 | 0.83 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2FFAR3LCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036334-B1 | ION DETECTOR CONSISTING OF PARTICLES WITH TARGET AND INDICATOR IONOPHORES DISTRIBUTED THEREIN | BECKMAN COULTER INC (US) | 2004-02-04 | — | — | EP | disclosed |
| US-6165796-A | Pipettable ion detector and method | BECKMAN COULTER, INC. (US) | 2000-12-26 | — | — | US | disclosed |
| EP-1036334-A1 | ION DETECTOR CONSISTING OF PARTICLES WITH TARGET AND INDICATOR IONOPHORES DISTRIBUTED THEREIN | Beckman Coulter, Inc. (US) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999027371-A1 | ION DETECTOR CONSISTING OF PARTICLES WITH TARGET AND INDICATOR IONOPHORES DISTRIBUTED THEREIN | BECKMAN COULTER, INC. (US) | 1999-06-03 | — | — | WO | disclosed |