Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21728097 | 0.82 | AR (0.44) | TRPV4ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL22140450 | 0.80 | TRPV4 (0.43) | TRPV4ALDH1A1HPGDKDM4EMEN1 | |
| SCHEMBL5665856 | 0.79 | ALDH1A1 (0.41) | ALDH1A1HPGDKDM4EMAPK1HSD17B10 | |
| SCHEMBL31431229 | 0.78 | MAPT (0.59) | TRPV4ALDH1A1HPGDKDM4EMAPK1 | |
| SCHEMBL30223652 | 0.78 | ALDH1A1 (0.58) | ALDH1A1HPGDKDM4EMAPK1HSD17B10 | |
| SCHEMBL28961155 | 0.78 | ALDH1A1 (0.58) | ALDH1A1HPGDKDM4EMAPK1HSD17B10 | |
| SCHEMBL506595 | 0.77 | ALDH1A1 (0.42) | ALDH1A1HPGDKDM4EMAPK1MEN1 | |
| SCHEMBL28051189 | 0.75 | KDM4E (0.57) | ALDH1A1HPGDKDM4EMAPTMEN1 | |
| SCHEMBL6817437 | 0.75 | TRPV4 (0.40) | TRPV4ALDH1A1HPGDKDM4EMAPK1 | |
| SCHEMBL31432318 | 0.75 | ALDH1A1 (0.47) | TRPV4ALDH1A1HPGDKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108191781-B | Substituted triazole derivative and application thereof in preparation of anti-tumor metastasis drugs | 浙江大学 | 2020-01-21 | — | — | CN | disclosed |
| CN-1529591-A | Method for synthesizing phenol-containing compounds | ʷ��˿�������ȳ�ķ����˾ | 2004-09-15 | — | — | CN | disclosed |
| US-20040110954-A1 | Methods of synthesizing phenol-contining compounds | SMITHKLINE BEECHAM CORPORATION | 2004-06-10 | — | — | US | disclosed |
| CN-1152675-C | IL-8 receptor antagonists | ʷ��˿�������ȳ�ķ����˾ | 2004-06-09 | — | — | CN | disclosed |
| EP-1191934-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-04 | — | — | EP | disclosed |
| EP-1383488-A2 | METHODS OF SYNTHESIZING PHENOL-CONTAINING COMPOUNDS | SmithKline Beecham Corporation (US) | 2004-01-28 | — | — | EP | disclosed |
| EP-0929302-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-31 | — | — | EP | disclosed |
| WO-2002079122-A2 | METHODS OF SYNTHESIZING PHENOL-CONTAINING COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-10 | — | — | WO | disclosed |
| EP-1191934-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-0957907-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2001-08-16 | — | — | EP | disclosed |
| US-6204294-B1 | GUANIDINE CONTAINING COMPOUNDS | SMITHKLINE BEECHAM CORPORATION | 2001-03-20 | — | — | US | disclosed |
| WO-2000076516-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |
| EP-0948330-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1999-12-01 | — | — | EP | disclosed |
| EP-0957907-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-24 | — | — | EP | disclosed |
| CN-1232398-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1999-10-20 | — | — | CN | disclosed |
| EP-0948330-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-13 | — | — | EP | disclosed |
| EP-0929302-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998006397-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-19 | — | — | WO | disclosed |
| WO-1998005328-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-12 | — | — | WO | disclosed |
| WO-1998005317-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110954-A1 | Methods of synthesizing phenol-contining compounds | COMT, BPHL, PNMT | TRPV4 2498/4885ALDH1A1 466/4885HPGD 33/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.