Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.57 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.57 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 3/20 | 0.56 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4509743 | 0.88 | LMNA (0.64) | LMNACHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL4514388 | 0.84 | LMNA (0.59) | LMNACHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL6551383 | 0.82 | SLC6A1 (0.52) | LMNABLMCYP1A2CYP2D6PMP22 | |
| SCHEMBL10874466 | 0.82 | LMNA (0.56) | LMNACHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL4520047 | 0.81 | LMNA (0.62) | LMNACHRM3CHRM2CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL10419888 | 0.81 | LMNA (0.62) | LMNACHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL4511928 | 0.80 | LMNA (0.65) | LMNACHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL4519711 | 0.80 | CHRM3 (0.60) | LMNACHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL4525215 | 0.79 | LMNA (0.59) | LMNACHRM3CHRM2CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL9702237 | 0.78 | CHRM3 (0.61) | LMNACHRM3CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385824-A2 | COMPOUNDS CO-INDUCING CHOLINERGIC UP-REGULATION AND INFLAMMATION DOWN-REGULATION AND USES THEREOF | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2004-02-04 | — | — | EP | disclosed |
| US-20020160988-A1 | Compounds co-inducing cholinergic up-regulation and inflammation down-regulation and uses thereof | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH | 2002-10-31 | — | — | US | disclosed |
| WO-2002065977-A2 | COMPOUNDS CO-INDUCING CHOLINERGIC UP-REGULATION AND INFLAMMATION DOWN-REGULATION AND USES THEREOF | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2002-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020160988-A1 | Compounds co-inducing cholinergic up-regulation and inflammation down-regulation and uses thereof | CHAT, ACHE, CHRNB2 | LMNA 4005/4885CHRM3 6/4885CHRM2 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.