Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | MAOA | P21397 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | GLA | P06280 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | TTR | P02766 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8958450 | 0.92 | KDM4E (0.62) | KDM4EMAOAALDH1A1CYP3A4GLA | |
| SCHEMBL891550 | 0.78 | MAOA (0.68) | KDM4EMAOAALDH1A1CYP3A4GLA | |
| Dibenzofuran SCHEMBL9651343 | 0.78 | KDM4E (0.61) | KDM4EMAOAALDH1A1CYP3A4GLA | |
| Dibenzofuran SCHEMBL7810840 | 0.78 | KDM4E (0.61) | KDM4EMAOAALDH1A1CYP3A4GLA | |
| SCHEMBL21961896 | 0.78 | ELANE (0.56) | KDM4EMAOAALDH1A1CYP3A4GLA | |
| Xanthone SCHEMBL10868526 | 0.74 | MAOA (0.69) | KDM4EMAOAALDH1A1CYP3A4GLA | |
| Xanthone SCHEMBL18138444 | 0.73 | MAOA (0.75) | KDM4EMAOAALDH1A1CYP3A4GLA | |
| Xanthone SCHEMBL28434710 | 0.73 | MAOA (0.95) | KDM4EMAOAALDH1A1CYP3A4GLA | |
| SCHEMBL9787769 | 0.72 | MAOA (0.74) | KDM4EMAOAALDH1A1CYP3A4GLA | |
| SCHEMBL30205812 | 0.72 | MAOA (0.57) | KDM4EMAOAALDH1A1CYP3A4GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1159335-B1 | CAPPING OF POLYPHENYLENE ETHER RESIN | GEN ELECTRIC (US) | 2004-12-08 | — | — | EP | disclosed |
| EP-1159335-A1 | CAPPING OF POLYPHENYLENE ETHER RESIN | GENERAL ELECTRIC COMPANY (US) | 2001-12-05 | — | — | EP | disclosed |
| US-6306978-B1 | Capping of polyphenylene ether resin | GENERAL ELECTRIC COMPANY | 2001-10-23 | — | — | US | disclosed |
| WO-2000046275-A1 | CAPPING OF POLYPHENYLENE ETHER RESIN | GENERAL ELECTRIC COMPANY (US) | 2000-08-10 | — | — | WO | disclosed |
| US-4760118-A | Reacting polyphenylene ether in melt with salicylic acid ester or substituted derivatives | GENERAL ELECTRIC COMPANY (US) | 1988-07-26 | — | — | US | disclosed |