Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 8/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7046185 | 0.88 | CDK5 (0.49) | LMNALTB4RMAPK8MAPK10 | |
| SCHEMBL6552063 | 0.88 | CNR1 (0.46) | HTTCNR1PARP1LMNAPOLB | |
| SCHEMBL7042512 | 0.88 | CNR1 (0.58) | CNR1PARP1TP53CNR2 | |
| SCHEMBL7046180 | 0.78 | EPHX2 (0.50) | CNR1LMNATP53CNR2 | |
| SCHEMBL7042653 | 0.77 | CYP2D6 (0.53) | LMNAPOLBMAPK8MAPK10 | |
| SCHEMBL7041816 | 0.77 | SMN1; SMN2 (0.53) | HTTCNR1LMNAPOLBCNR2 | |
| SCHEMBL7047760 | 0.77 | LTB4R (0.49) | LMNAPOLBLTB4R | |
| SCHEMBL7045706 | 0.77 | CNR1 (0.56) | CNR1CNR2 | |
| SCHEMBL6552425 | 0.75 | LTB4R (0.57) | HTTPARP1LTB4R | |
| SCHEMBL7042633 | 0.75 | CNR1 (0.52) | CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003007887-A2 | SUBSTITUTED IMIDAZOLES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-01-30 | — | — | WO | claimed |
| EP-1482794-A1 | METHOD OF TREATMENT OR PREVENTION OF OBESITY | Merck & Co., Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003075660-A1 | METHOD OF TREATMENT OR PREVENTION OF OBESITY | MERCK & CO., INC. (US) | 2003-09-18 | — | — | WO | disclosed |
| WO-2003007887-A2 | SUBSTITUTED IMIDAZOLES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-01-30 | — | — | WO | disclosed |