Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 1/20 | 0.57 |
| ▸ | RNASEH1 | O60930 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6551997 | 0.85 | PIN1 (0.45) | LTB4RALDH1A1GAAKDM4EHSD17B10 | |
| SCHEMBL7044697 | 0.85 | RHEB (0.45) | LTB4RALDH1A1KDM4EKDM4C | |
| SCHEMBL6553452 | 0.83 | TDP1 (0.50) | LTB4RALDH1A1KMT2ATSHR | |
| SCHEMBL7047760 | 0.82 | LTB4R (0.49) | LTB4RALDH1A1GAAHSD17B10KMT2A | |
| SCHEMBL22048694 | 0.80 | LTB4R (0.50) | LTB4RRNASEH1ALDH1A1HPGDGAA | |
| SCHEMBL2943501 | 0.77 | LTB4R (0.62) | LTB4RALDH1A1HPGDGAAKDM4E | |
| SCHEMBL6553813 | 0.76 | MMP2 (0.48) | LTB4RALDH1A1KDM4EKMT2ATSHR | |
| SCHEMBL7042642 | 0.76 | ALOX5 (0.57) | LTB4RALDH1A1CYP2C9KMT2A | |
| SCHEMBL6551978 | 0.75 | HTT (0.49) | LTB4RHTTPARP1 | |
| SCHEMBL7044700 | 0.75 | SMN1; SMN2 (0.52) | ALDH1A1HPGDKDM4EHTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482794-A1 | METHOD OF TREATMENT OR PREVENTION OF OBESITY | Merck & Co., Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003075660-A1 | METHOD OF TREATMENT OR PREVENTION OF OBESITY | MERCK & CO., INC. (US) | 2003-09-18 | — | — | WO | disclosed |
| WO-2003007887-A2 | SUBSTITUTED IMIDAZOLES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-01-30 | — | — | WO | disclosed |