Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 6/20 | 0.49 |
| ▸ | THRA | P10827 | 5/20 | 0.49 |
| ▸ | PPARG | P37231 | 2/20 | 0.49 |
| ▸ | PCNA | P12004 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TTR | P02766 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4809817 | 0.92 | THRB (0.46) | THRBTHRAPPARGPCNAPDCD1 | |
| SCHEMBL6554347 | 0.88 | THRB (0.44) | THRBTHRAPPARGPCNAPTPN1 | |
| SCHEMBL4818194 | 0.84 | SLC7A5 (0.53) | THRBTHRAPPARGPCNASLC7A5 | |
| SCHEMBL4812275 | 0.82 | THRB (0.42) | THRBTHRAPPARGPCNASLC7A5 | |
| SCHEMBL4810919 | 0.81 | THRA (0.50) | THRBTHRAPPARGPDCD1CD274 | |
| SCHEMBL188320 | 0.81 | SLC7A5 (0.57) | THRBSLC7A5MEN1KMT2ALMNA | |
| SCHEMBL188321 | 0.81 | SLC7A5 (0.57) | THRBSLC7A5MEN1KMT2ALMNA | |
| SCHEMBL2129884 | 0.81 | SLC7A5 (0.57) | THRBSLC7A5MEN1KMT2ALMNA | |
| SCHEMBL4809787 | 0.80 | PTPN1 (0.64) | THRBTHRAPPARGSLC7A5PDCD1 | |
| SCHEMBL4899376 | 0.80 | THRA (0.64) | THRBTHRAPPARGSLC7A5PDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1387825-A1 | THYROID HORMONE RECEPTOR ANTAGONISTS FOR CARDIAC & METABOLIC DISORDERS II | KARO BIO AB (SE) | 2004-02-11 | — | — | EP | claimed |
| WO-2002092550-A1 | THYROID HORMONE RECEPTOR ANTAGONISTS FOR CARDIAC AND METABOLIC DISORDERS II | KARO BIO AB (SE) | 2002-11-21 | — | — | WO | claimed |