Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.64 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.51 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.51 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 4/20 | 0.47 |
| ▸ | THRA | P10827 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.46 |
| ▸ | ALPI | P09923 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | XIAP | P98170 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4815513 | 0.80 | SLC1A5 (0.49) | PTPN1PDCD1CD274SLC1A5THRB | |
| SCHEMBL6553667 | 0.80 | THRB (0.49) | PTPN1PDCD1CD274THRBTHRA | |
| SCHEMBL4896380 | 0.79 | THRB (0.73) | THRBTHRAMAPTLMNAALPG | |
| SCHEMBL4812326 | 0.78 | THRA (0.64) | PDCD1CD274THRBTHRAPPARG | |
| SCHEMBL4899376 | 0.78 | THRA (0.64) | PDCD1CD274THRBTHRAPPARG | |
| SCHEMBL4817169 | 0.76 | THRA (0.51) | THRBTHRAPPARGSLC7A5ALPI | |
| SCHEMBL4808172 | 0.76 | THRA (0.67) | SLC1A5THRBTHRAMAPTALDH1A1 | |
| SCHEMBL4818194 | 0.75 | SLC7A5 (0.53) | PDCD1CD274THRBTHRAMAPT | |
| SCHEMBL4810919 | 0.75 | THRA (0.50) | PDCD1CD274THRBTHRAPPARG | |
| SCHEMBL268942 | 0.74 | PKM (0.58) | PTPN1SLC1A5THRBMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7319096-B2 | Thyroid hormone receptor antagonists for cardiac and metabolic disorders II | KARO BIO AB (SE) | 2008-01-15 | — | — | US | claimed |
| US-20040220147-A1 | Thyroid hormone receptor antagonists for cardiac and metabolic disorders ll | KARO BIO AB (SE) | 2004-11-04 | — | — | US | claimed |
| EP-1387825-A1 | THYROID HORMONE RECEPTOR ANTAGONISTS FOR CARDIAC & METABOLIC DISORDERS II | KARO BIO AB (SE) | 2004-02-11 | — | — | EP | claimed |
| WO-2002092550-A1 | THYROID HORMONE RECEPTOR ANTAGONISTS FOR CARDIAC AND METABOLIC DISORDERS II | KARO BIO AB (SE) | 2002-11-21 | — | — | WO | claimed |
| US-7319096-B2 | Thyroid hormone receptor antagonists for cardiac and metabolic disorders II | KARO BIO AB (SE) | 2008-01-15 | — | — | US | disclosed |
| US-20040220147-A1 | Thyroid hormone receptor antagonists for cardiac and metabolic disorders ll | KARO BIO AB (SE) | 2004-11-04 | — | — | US | disclosed |
| EP-1387825-A1 | THYROID HORMONE RECEPTOR ANTAGONISTS FOR CARDIAC & METABOLIC DISORDERS II | KARO BIO AB (SE) | 2004-02-11 | — | — | EP | disclosed |
| WO-2002092550-A1 | THYROID HORMONE RECEPTOR ANTAGONISTS FOR CARDIAC AND METABOLIC DISORDERS II | KARO BIO AB (SE) | 2002-11-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040220147-A1 | Thyroid hormone receptor antagonists for cardiac and metabolic disorders ll | TSHR, TRHR, THRA | PTPN1 619/4885PDCD1 3128/4885CD274 2029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.