Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 8/20 | 0.59 |
| ▸ | PPARG | P37231 | 6/20 | 0.59 |
| ▸ | PPARD | Q03181 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | GMNN | O75496 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | USP1 | O94782 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6552333 | 0.90 | PPARA (0.73) | PPARAPPARGPPARDALDH1A1GMNN | |
| SCHEMBL6552622 | 0.84 | PPARA (0.80) | PPARAPPARGPPARDALDH1A1GMNN | |
| SCHEMBL4265257 | 0.74 | PPARA (1.00) | PPARAPPARGPPARDALDH1A1GMNN | |
| Gw7647 SCHEMBL361372 | 0.73 | PPARA (1.00) | PPARAPPARGPPARDALDH1A1GMNN | |
| SCHEMBL22100299 | 0.72 | PPARA (0.98) | PPARAPPARGPPARDALDH1A1GMNN | |
| SCHEMBL6553624 | 0.69 | PPARA (0.43) | PPARAPPARGPPARDALDH1A1GMNN | |
| SCHEMBL6553742 | 0.68 | ALDH1A1 (0.40) | ALDH1A1CYP1A2POLBCYP3A4MAPT | |
| SCHEMBL6553638 | 0.67 | PPARA (0.40) | PPARAPPARGPPARDALDH1A1GMNN | |
| SCHEMBL6553633 | 0.66 | PPARA (0.50) | PPARAPPARGPPARDALDH1A1GMNN | |
| SCHEMBL21569126 | 0.66 | PPARA (0.63) | PPARAPPARGPPARDALDH1A1GMNN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149063-B1 | UREIDO-THIOBUTYRIC ACID DERIVATIVES AS PPAR-AGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-1149063-A2 | UREIDO-THIOBUTYRIC ACID DERIVATIVES AS PPAR-AGONISTS | GLAXO GROUP LIMITED (GB) | 2001-10-31 | — | — | EP | disclosed |
| US-6306854-B1 | ARYLTHIOALKYLACIDS AND ALKYL UREAS | GLAXOSMITHKLINE | 2001-10-23 | — | — | US | disclosed |
| WO-2000023407-A2 | UREIDO-THIOBUTYRIC ACID DERIVATIVES AS PPAR-AGONISTS | GLAXO GROUP LIMITED (GB) | 2000-04-27 | — | — | WO | disclosed |