Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | FNTA | P49354 | 1/20 | 0.42 |
| ▸ | FNTB | P49356 | 1/20 | 0.42 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11611947 | 0.81 | FNTA (0.43) | CYP11B1CYP11B2KEAP1FNTAFNTB | |
| SCHEMBL18536815 | 0.80 | CYP11B1 (0.48) | CYP11B1CYP11B2KMT2ATDP1LMNA | |
| SCHEMBL7300346 | 0.79 | SLC7A5 (0.47) | FNTAFNTBPGGT1BKMT2AMEN1 | |
| SCHEMBL7167349 | 0.77 | CYP11B1 (0.48) | CYP11B1CYP11B2KMT2AP2RX4TDP1 | |
| SCHEMBL11463027 | 0.77 | DPP4 (0.40) | FNTAFNTBPGGT1BKMT2AP2RX4 | |
| SCHEMBL22784007 | 0.76 | ALDH1A1 (0.45) | CYP11B1CYP11B2KMT2AP2RX4TDP1 | |
| SCHEMBL7273866 | 0.75 | ITGA4 (0.47) | ALDH1A1 | |
| SCHEMBL2789678 | 0.74 | NR1H2 (0.38) | CYP11B1CYP11B2 | |
| SCHEMBL9092547 | 0.73 | CYP11B1 (0.73) | CYP11B1CYP11B2FFAR1KEAP1 | |
| SCHEMBL13601988 | 0.69 | CYP11B1 (0.40) | CYP11B1CYP11B2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708179-B1 | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use | LILLY CO ELI (US) | 2004-12-22 | — | — | EP | disclosed |
| US-5512549-A | ANTIDIABETIC AGENTS | ELI LILLY AND COMPANY (US) | 1996-04-30 | — | — | US | disclosed |
| EP-0708179-A2 | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use | ELI LILLY AND COMPANY (US) | 1996-04-24 | — | — | EP | disclosed |