Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 4/20 | 0.43 |
| ▸ | THRB | P10828 | 4/20 | 0.43 |
| ▸ | CYP4Z1 | Q86W10 | 2/20 | 0.42 |
| ▸ | CYP4F11 | Q9HBI6 | 1/20 | 0.40 |
| ▸ | CYP4F12 | Q9HCS2 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 4/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 4/20 | 0.38 |
| ▸ | RARB | P10826 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6405545 | 0.96 | CYP4Z1 (0.41) | THRATHRBCYP4Z1CYP4F11CYP4F12 | |
| SCHEMBL6406595 | 0.89 | CYP4A11 (0.47) | THRATHRBCYP4Z1CYP4F11CYP4F12 | |
| SCHEMBL6404151 | 0.87 | CYP4A11 (0.46) | CYP4Z1CYP4F11CYP4F12ALOX5CYP4F2 | |
| SCHEMBL6394479 | 0.77 | CA12 (0.56) | THRATHRBCYP4F2CYP4A11TDP1 | |
| SCHEMBL28564755 | 0.76 | CYP4Z1 (0.49) | THRATHRBCYP4Z1CYP4F11CYP4F12 | |
| SCHEMBL9869627 | 0.75 | ALDH1A1 (0.50) | GAACYP1A2 | |
| SCHEMBL3056656 | 0.74 | CA12 (0.56) | THRATHRBCYP4F2CYP4A11TDP1 | |
| SCHEMBL6404492 | 0.73 | ALDH1A1 (0.41) | THRATHRBALOX5MAPK1 | |
| SCHEMBL8879300 | 0.73 | CYP4Z1 (0.59) | THRATHRBCYP4Z1CYP4F11CYP4F12 | |
| SCHEMBL5755875 | 0.71 | HPGD (0.44) | THRATHRBPLA2G1BATG4BRARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487800-A1 | PHENANTHRIDINONES AS PARP INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003080581-A1 | PHENANTHRIDINONES AS PARP INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-10-02 | — | — | WO | disclosed |