Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | RORC | P51449 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2391163 | 0.88 | HSD17B10 (0.50) | LMNAHSD17B10KMT2AMEN1ALDH1A1 | |
| SCHEMBL3472278 | 0.87 | HSD17B10 (0.49) | LMNAHSD17B10KMT2AMEN1ALDH1A1 | |
| SCHEMBL11740225 | 0.83 | ALDH1A1 (0.51) | ALDH1A1MAPTTP53TSHRMAPK1 | |
| SCHEMBL3379925 | 0.83 | ALDH1A1 (0.47) | KMT2AMEN1ALDH1A1MAPTCYP3A4 | |
| SCHEMBL6556706 | 0.82 | MAPT (0.55) | LMNAHSD17B10KMT2AMEN1ALDH1A1 | |
| SCHEMBL6557884 | 0.82 | HSD17B10 (0.51) | LMNAHSD17B10KMT2AMEN1ALDH1A1 | |
| SCHEMBL14744361 | 0.82 | ALDH1A1 (0.44) | LMNAKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL2009030 | 0.82 | HSD17B10 (0.50) | LMNAHSD17B10KMT2AMEN1ALDH1A1 | |
| Dimethylamine SCHEMBL22445184 | 0.81 | MEN1 (0.51) | LMNAHSD17B10KMT2AMEN1ALDH1A1 | |
| SCHEMBL8744236 | 0.80 | CRHBP (0.52) | LMNAKMT2AMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051279-B2 | Substituted isoquinolinones and quinazolinones | NOVARTIS AG (CH) | 2015-06-09 | — | — | US | disclosed |
| US-20130281473-A1 | SUBSTITUTED ISOQUINOLINONES AND QUINAZOLINONES | NOVARTIS AG (CH) | 2013-10-24 | — | — | US | disclosed |
| US-8440693-B2 | Substituted isoquinolinones and quinazolinones | NOVARTIS AG (CH) | 2013-05-14 | — | — | US | disclosed |
| US-20110230457-A1 | Substituted Isoquinolinones and Quinazolinones | NOVARTIS AG (CH) | 2011-09-22 | — | — | US | disclosed |
| EP-1100483-B1 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | ABBOTT LAB (US) | 2004-09-29 | — | — | EP | disclosed |
| EP-1100483-A2 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | Abbott Laboratories (US) | 2001-05-23 | — | — | EP | disclosed |
| US-6166013-A | Glucocortiocoid-selective agents | ABBOTT LABORATORIES (US) | 2000-12-26 | — | — | US | disclosed |
| WO-2000006137-A2 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 2000-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230457-A1 | Substituted Isoquinolinones and Quinazolinones | MDM4, MDM2, TP53 | LMNA 1863/4885HSD17B10 2843/4885KMT2A 1137/4885 |
| US-20130281473-A1 | SUBSTITUTED ISOQUINOLINONES AND QUINAZOLINONES | MDM4, MDM2, TP53 | LMNA 1863/4885HSD17B10 2843/4885KMT2A 1137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.